Protein: SNX5
Sorting nexin-5

Gene: SNX5
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q9Y5X3

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0001891 - phagocytic cup
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005903 - brush border

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1112005

SNX1
Sorting nexin-1

6

19

Small-scale

0.947

High

1462657

DYN3
Dynamin-3

3

13

High-throughput

0.861

High

255509

SNX2
Sorting nexin-2

2

19

High-throughput

0.793

High

1366013

APBP2
Amyloid protein-binding protein 2

3

3

High-throughput

0.675

High

333273

VAPB
Vesicle-associated membrane protein-associated protein B/C

3

3

High-throughput

0.667

High

571696

HCLS1
Hematopoietic lineage cell-specific protein

2

9

High-throughput

0.628

High

1459695

MLX
Max-like protein X

2

3

High-throughput

0.628

High

245820

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

2

1

Small-scale

0.620

High

1396883

SNX27
Sorting nexin-27

1

3

High-throughput

0.618

High

1491767

SNX5
Sorting nexin-5

1

17

Small-scale

0.618

High

61860

F221A
Protein FAM221A

3

2

High-throughput

0.609

High

618506

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

3

5

High-throughput

0.609

High

1328484

CK042
Uncharacterized protein C11orf42

3

1

High-throughput

0.609

High

1404999

GA2L1
GAS2-like protein 1

3

2

High-throughput

0.609

High

1447634

BIN3
Bridging integrator 3

3

7

High-throughput

0.609

High

700492

PSB8
Proteasome subunit beta type-8

2

1

High-throughput

0.606

High

709035

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

916211

BIEA
Biliverdin reductase A

2

0

High-throughput

0.585

High

243427

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

540776

LAMP1
Lysosome-associated membrane glycoprotein 1

2

12

High-throughput

0.584

High

191982

TEX28
Testis-specific protein TEX28

2

1

High-throughput

0.574

High

1235397

KLH10
Kelch-like protein 10

2

4

High-throughput

0.574

High

1322189

CA087
Uncharacterized protein C1orf87

2

2

High-throughput

0.574

High

1458697

DJB11
DnaJ homolog subfamily B member 11

2

2

High-throughput

0.570

High

169809

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

8

Small-scale

0.561

High

1295138

F90A1
Protein FAM90A1

2

3

High-throughput

0.558

High

345134

RIGI
Antiviral innate immune response receptor RIG-I

1

1

Small-scale

0.552

High

922533

CLH2
Clathrin heavy chain 2

1

3

Small-scale

0.552

High

1491768

NPTN
Neuroplastin

2

3

High-throughput

0.549

High

1154202

ITSN1
Intersectin-1

1

4

High-throughput

0.541

High

1295608

MIB1
E3 ubiquitin-protein ligase MIB1

1

3

Small-scale

0.541

High

256520

TOM1
Target of Myb1 membrane trafficking protein

1

4

High-throughput

0.536

High

414925

P53
Cellular tumor antigen p53

1

1

High-throughput

0.536

High

530673

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

933551

S12A3
Solute carrier family 12 member 3

1

3

High-throughput

0.536

High

1252018

STAC2
SH3 and cysteine-rich domain-containing protein 2

1

17

High-throughput

0.536

High

1335116

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

187581

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.529

High

164485

NRP1
Neuropilin-1

1

5

High-throughput

0.527

High

219254

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

390831

TFR1
Transferrin receptor protein 1

1

2

High-throughput

0.515

High

1195622

ARI4B
AT-rich interactive domain-containing protein 4B

1

0

High-throughput

0.513

High

287209

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

2

High-throughput

0.508

High

186148

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

155717

CUX2
Homeobox protein cut-like 2

1

3

High-throughput

0.489

High

482651

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

5

High-throughput

0.489

High

1180769

CEA16
Cell adhesion molecule CEACAM16

1

1

High-throughput

0.489

High

1181038

DB136
Defensin beta 136

1

3

High-throughput

0.489

High

1228747

C102B
Coiled-coil domain-containing protein 102B

1

3

High-throughput

0.489

High

1360059

IBPL1
Insulin-like growth factor-binding protein-like 1

1

7

High-throughput

0.489

High

1381929

C102A
Coiled-coil domain-containing protein 102A

1

3

High-throughput

0.489

High

1397816

ODAD1
Outer dynein arm-docking complex subunit 1

1

6

High-throughput

0.489

High

1434624

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

6

High-throughput

0.489

High

1439388

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

1449074

SPNXB
Sperm protein associated with the nucleus on the X chromosome B1

1

2

High-throughput

0.489

High

1490767

NTNG1
Netrin-G1

1

5

High-throughput

0.489

High

1491441

HYOU1
Hypoxia up-regulated protein 1

1

5

High-throughput

0.489

High

1158628

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

1026303

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.481

High

189953

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

219018

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

317700

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.479

High

374306

RASN
GTPase NRas

1

15

High-throughput

0.479

High

375045

RASH
GTPase HRas

1

13

High-throughput

0.479

High

376150

RASK
GTPase KRas

1

15

High-throughput

0.479

High

400045

CATA
Catalase

1

1

High-throughput

0.479

High

401777

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

439892

INSR
Insulin receptor

1

20

High-throughput

0.479

High

465702

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

548652

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.479

High

556446

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

562516

LAMP2
Lysosome-associated membrane glycoprotein 2

1

12

High-throughput

0.479

High

604290

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

631594

RAB5A
Ras-related protein Rab-5A

1

11

High-throughput

0.479

High

975345

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

976698

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.479

High

1093216

STK4
Serine/threonine-protein kinase 4

1

7

High-throughput

0.479

High

1364744

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1380300

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.479

High

1383728

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

1399133

SCLT1
Sodium channel and clathrin linker 1

1

3

High-throughput

0.479

High

1400358

FMNL2
Formin-like protein 2

1

3

High-throughput

0.479

High

1433023

DNJC5
DnaJ homolog subfamily C member 5

1

11

High-throughput

0.479

High

1447047

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1454804

ANFY1
Rabankyrin-5

1

5

High-throughput

0.479

High

1459477

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1462792

LAMP3
Lysosome-associated membrane glycoprotein 3

1

12

High-throughput

0.479

High

720081

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.464

High

1131253

MESD
LRP chaperone MESD

1

1

High-throughput

0.464

High

832665

AQP2
Aquaporin-2

1

0

Small-scale

0.460

High

1106767

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1290536

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

Small-scale

0.458

High

1333386

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1448603

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

477273

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

High-throughput

0.457

High

142450

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

1156253

ZYX
Zyxin

1

0

Small-scale

0.438

High

249069

NRP2
Neuropilin-2

1

5

High-throughput

0.437

High

590148

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

696988

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

769632

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

1159923

OCLN
Occludin

1

2

High-throughput

0.437

High

1233613

LTOR1
Ragulator complex protein LAMTOR1

1

7

High-throughput

0.437

High

1256288

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

1277048

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1415084

LRC61
Leucine-rich repeat-containing protein 61

1

2

High-throughput

0.437

High

1431805

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1452736

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

262347

SCN2B
Sodium channel regulatory subunit beta-2

1

2

High-throughput

0.407

High

330388

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

517313

GAGE1
G antigen 1

1

1

High-throughput

0.407

High

1104178

RM49
Large ribosomal subunit protein mL49

1

3

High-throughput

0.407

High

1332072

BANP
Protein BANP

2

0

High-throughput

0.316

High

1420868

SEM4C
Semaphorin-4C

2

0

High-throughput

0.313

High

931470

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.279

Low

1289936

F124A
Protein FAM124A

1

0

High-throughput

0.279

Low

1454574

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.279

Low

261901

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

725686

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

0

High-throughput

0.249

Low

947087

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

835426

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025