HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 505
+	Mm
		435883 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		HCK_MOUSE (1-505): 0: 564: 61.93
+	Hs
		411545 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		LCK_HUMAN (1-505): 0: 569: 59.15
+	Mm
		763392 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		FYN_MOUSE (1-503): 0: 561: 54.56
+	Hs
		155829 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		411936 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		FYN_HUMAN (1-503): 0: 562: 54.75
+	Mm
		536205 FGR_MOUSE (3-124): 4.13e-35: 128: 24.22		FGR_MOUSE (1-503): 0: 562: 55.13
+	Mm
		639445 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		LYN_MOUSE (1-505): 0: 554: 60.16
+	Hs
		411969 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		176351 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		LYN_HUMAN (1-505): 0: 551: 59.77
+	Rn
		693648 CSK_RAT (3-131): 2.9e-35: 127: 23.26		SRC_RAT (1-503): 0: 557: 54.41
+	Hs
		411946 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		YES_HUMAN (1-503): 0: 555: 53.15
+	Dm
		1360389 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		SRC42_DROME (1-503): 0: 542: 50.39
+	Hs
		412071 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		FRK_HUMAN (32-502): 1.83e-179: 515: 45.94
+	Hs
		412070 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ABL2_HUMAN (8-503): 2.23e-165: 500: 38.67
+	Hs
		176332 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Hs
		69199 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		A9UF07_HUMAN (54-504): 8.4e-157: 490: 41.09
+	Hs
		337307 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Hs
		412155 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ITK_HUMAN (29-496): 7.21e-159: 466: 36.18
+	Hs
		412147 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Hs
		412066 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CSK_HUMAN (51-495): 1.16e-155: 452: 36.54