HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: DAPP1 (Q9UN19)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
Gene: DAPP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	23322602
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 280
+	Mm
		763401 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		Q91YX7_MOUSE (18-276): 4.55e-59: 203: 24.16
+	Mm
		763392 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		FYN_MOUSE (4-280): 2.42e-57: 194: 18.77
+	Dm
		1360389 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		SRC42_DROME (4-280): 1.17e-57: 194: 17.93
+	Mm
		639445 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		LYN_MOUSE (3-280): 2.45e-55: 187: 18.37
+	Hs
		155829 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Hs
		411936 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		FYN_HUMAN (4-280): 4.46e-57: 193: 18.77
+	Hs
		411946 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		YES_HUMAN (4-280): 3.38e-57: 193: 19.11
+	Hs
		176351 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		411969 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Mm
		536205 FGR_MOUSE (3-124): 4.13e-35: 128: 24.22		FGR_MOUSE (4-280): 1.65e-55: 188: 18.77
+	Hs
		176332 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ABL1_HUMAN (8-280): 6.5e-51: 181: 17.61
+	Hs
		337307 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ABL1_HUMAN (8-280): 6.5e-51: 181: 17.61
+	Hs
		411545 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		69199 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		A9UF07_HUMAN (8-280): 3.03e-49: 176: 17.61
+	Mm
		435883 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		HCK_MOUSE (3-280): 1.79e-49: 172: 19.73
+	Hs
		155835 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		BLK_HUMAN (4-280): 6.05e-48: 168: 17.47
+	Mm
		763403 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		NCK1_MOUSE (34-127): 8.58e-40: 144: 34.04
+	Hs
		155832 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		PLCG1_HUMAN (4-184): 1.67e-22: 99.1: 23.00
+	Mm
		763400 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		PLCG2_MOUSE (4-198): 3.76e-22: 97.9: 20.83
+	Hs
		155831 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		PLCG2_HUMAN (8-198): 3.87e-21: 94.8: 20.28