HitPredict

Interactor 1: RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Gene: POLR3A

Interactor 2: RPC5 (Q9NVU0)
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
Gene: POLR3E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	26496610, 28514442, 12391170, 33961781, 35271311, 24981860
Identification Methods	affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol GO:0042797 - tRNA transcription by RNA polymerase III GO:0045087 - innate immune response and 1 others more... GO:0051607 - defense response to virus
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 708
+	Hs
		625065 RPB1_HUMAN (2-1382): 0: 1534: 32.10		RPC5_HUMAN (1-708): 0: 1231: 100.00
+	Sc
		375600 RPC1_YEAST (9-1383): 0: 1530: 49.93		RPC5_YEAST (8-210): 2.28e-56: 195: 22.33
+	Hs
		317168 RPA1_HUMAN (1147-1366): 4.77e-51: 200: 23.87		RPC5_HUMAN (1-708): 0: 1231: 100.00