Protein: BLK
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)

Gene: BLK
Organism: Homo sapiens
Interactions: 194
UniProt ID: P51451

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211982

EFS
Embryonal Fyn-associated substrate

5

20

High-throughput

0.930

High

827706

STAT3
Signal transducer and activator of transcription 3

5

16

High-throughput

0.925

High

362990

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.924

High

461284

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

468194

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

902840

CDC37
Hsp90 co-chaperone Cdc37

3

14

High-throughput

0.839

High

155925

SOCS3
Suppressor of cytokine signaling 3

2

20

High-throughput

0.783

High

164852

SH21B
SH2 domain-containing protein 1B

2

20

High-throughput

0.783

High

699655

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

High-throughput

0.783

High

855837

CRKL
Crk-like protein

2

20

High-throughput

0.783

High

902831

SLAP1
Src-like-adapter

2

18

High-throughput

0.783

High

902832

GRB10
Growth factor receptor-bound protein 10

2

18

High-throughput

0.783

High

902835

BIRC2
Baculoviral IAP repeat-containing protein 2

2

6

High-throughput

0.783

High

902870

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.783

High

410721

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

902836

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

2

7

High-throughput

0.776

High

443271

CDK1
Cyclin-dependent kinase 1

2

12

High-throughput

0.737

High

902861

CCD33
Coiled-coil domain-containing protein 33

3

3

High-throughput

0.733

High

902850

ANR54
Ankyrin repeat domain-containing protein 54

2

15

High-throughput

0.726

High

902907

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

15

High-throughput

0.700

High

472028

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532063

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

902834

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

191207

TLR3
Toll-like receptor 3

1

13

High-throughput

0.691

High

252336

TLR2
Toll-like receptor 2

1

12

High-throughput

0.691

High

440002

LCK
Tyrosine-protein kinase Lck

1

18

High-throughput

0.691

High

463410

LYN
Tyrosine-protein kinase Lyn

1

19

High-throughput

0.691

High

573391

ENPL
Endoplasmin

1

20

High-throughput

0.691

High

876780

KC1A
Casein kinase I isoform alpha

1

4

High-throughput

0.691

High

902813

IRAK1
Interleukin-1 receptor-associated kinase 1

1

3

High-throughput

0.691

High

902833

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

13

High-throughput

0.691

High

902860

TAGAP
T-cell activation Rho GTPase-activating protein

1

19

High-throughput

0.691

High

425384

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.665

High

443723

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

3

4

High-throughput

0.650

High

193235

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.647

High

599277

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

17

Small-scale

0.647

High

641532

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

786988

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.647

High

902839

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

902898

F217B
Protein FAM217B

3

0

High-throughput

0.638

High

286765

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.621

High

902852

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

2

High-throughput

0.618

High

902854

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

2

High-throughput

0.618

High

902863

LRTM2
Leucine-rich repeat and transmembrane domain-containing protein 2

1

3

High-throughput

0.618

High

902812

BLK
Tyrosine-protein kinase Blk

1

18

High-throughput

0.618

High

166276

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

3

High-throughput

0.611

High

255520

CYTIP
Cytohesin-interacting protein

2

20

High-throughput

0.611

High

658517

GLRA2
Glycine receptor subunit alpha-2

2

2

High-throughput

0.611

High

902845

GLYR1
Cytokine-like nuclear factor N-PAC

2

1

High-throughput

0.611

High

74331

ZBT42
Zinc finger and BTB domain-containing protein 42

2

3

High-throughput

0.606

High

269159

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

878418

PAXI
Paxillin

2

20

High-throughput

0.606

High

899788

FXR1
RNA-binding protein FXR1

2

5

High-throughput

0.606

High

900253

FXR2
RNA-binding protein FXR2

2

5

High-throughput

0.606

High

902897

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

902903

STAP2
Signal-transducing adaptor protein 2

2

4

High-throughput

0.606

High

902910

IKZF3
Zinc finger protein Aiolos

2

7

High-throughput

0.606

High

869824

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

2

0

High-throughput

0.602

High

902865

BANK1
B-cell scaffold protein with ankyrin repeats

2

4

Small-scale

0.601

High

474555

VIME
Vimentin

2

8

High-throughput

0.594

High

902847

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

665553

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

2

High-throughput

0.574

High

415438

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

452204

PDIA1
Protein disulfide-isomerase

2

6

High-throughput

0.571

High

457317

TBB5
Tubulin beta chain

2

8

High-throughput

0.571

High

462305

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

13

High-throughput

0.571

High

487106

PARP1
Poly [ADP-ribose] polymerase 1

2

7

High-throughput

0.571

High

534802

BIP
Endoplasmic reticulum chaperone BiP

2

17

High-throughput

0.571

High

801230

HSPA9
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

902825

DSG1
Desmoglein-1

2

10

High-throughput

0.571

High

902849

ZN774
Zinc finger protein 774

2

4

High-throughput

0.553

High

902874

ZBT8A
Zinc finger and BTB domain-containing protein 8A

2

7

High-throughput

0.553

High

902879

JKIP1
Janus kinase and microtubule-interacting protein 1

2

15

High-throughput

0.553

High

902881

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

2

3

High-throughput

0.553

High

902889

SSBP3
Single-stranded DNA-binding protein 3

2

2

High-throughput

0.553

High

519856

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

63983

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.536

High

124754

AIP
AH receptor-interacting protein

1

15

High-throughput

0.536

High

214188

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

4

High-throughput

0.536

High

254093

CTND1
Catenin delta-1

1

17

High-throughput

0.536

High

275806

CAD16
Cadherin-16

1

10

High-throughput

0.536

High

340853

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

10

High-throughput

0.536

High

342397

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

1

1

High-throughput

0.536

High

408748

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.536

High

565827

EF2
Elongation factor 2

1

5

High-throughput

0.536

High

642534

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

2

High-throughput

0.536

High

680282

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

719767

V2R
Vasopressin V2 receptor

1

6

High-throughput

0.536

High

772682

MYH9
Myosin-9

1

5

High-throughput

0.536

High

821267

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

868341

CDX1
Homeobox protein CDX-1

1

6

High-throughput

0.536

High

875874

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

881834

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

898955

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

899302

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

902818

CXCR4
C-X-C chemokine receptor type 4

1

8

High-throughput

0.536

High

902824

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

902841

CCL15
C-C motif chemokine 15

1

2

High-throughput

0.536

High

902844

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

1

High-throughput

0.536

High

902851

FXL22
F-box and leucine-rich protein 22

1

1

High-throughput

0.536

High

902869

NICA
Nicastrin

1

2

High-throughput

0.536

High

902882

MYCT
Proton myo-inositol cotransporter

1

2

High-throughput

0.536

High

902883

DCE1
Glutamate decarboxylase 1

1

5

High-throughput

0.536

High

902884

PHB2
Prohibitin-2

1

1

High-throughput

0.536

High

902885

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

902895

CNO10
CCR4-NOT transcription complex subunit 10

1

2

High-throughput

0.536

High

902902

GBG12

1

3

High-throughput

0.536

High

902904

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

7

High-throughput

0.536

High

902908

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.536

High

256598

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

12

High-throughput

0.521

High

902876

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

2

High-throughput

0.521

High

651228

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.515

High

583931

KCNE1
Potassium voltage-gated channel subfamily E member 1

1

0

High-throughput

0.513

High

599719

YBOX3
Y-box-binding protein 3

1

0

High-throughput

0.513

High

902819

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.513

High

902820

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.513

High

902853

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.513

High

902855

ABCA9
ATP-binding cassette sub-family A member 9

1

0

High-throughput

0.513

High

902866

OR5C1
Olfactory receptor 5C1

1

0

High-throughput

0.513

High

902873

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.513

High

902875

FBX17
F-box only protein 17

1

0

High-throughput

0.513

High

902892

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.513

High

902894

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

902906

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.513

High

902909

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.513

High

522064

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.501

High

902826

UBE3A
Ubiquitin-protein ligase E3A

1

16

Small-scale

0.501

High

902828

B2CL1
Bcl-2-like protein 1

1

3

Small-scale

0.501

High

902914

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

281196

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.489

High

287261

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.489

High

902821

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

3

High-throughput

0.489

High

902823

CTG1B
Cancer/testis antigen 1

1

1

High-throughput

0.489

High

902842

RTN1
Reticulon-1

1

4

High-throughput

0.489

High

902857

DJC10
DnaJ homolog subfamily C member 10

1

5

High-throughput

0.489

High

902868

BBX
HMG box transcription factor BBX

1

3

High-throughput

0.489

High

902871

AP3S1
AP-3 complex subunit sigma-1

1

5

High-throughput

0.489

High

902878

ARL5B
ADP-ribosylation factor-like protein 5B

1

4

High-throughput

0.489

High

902880

RBM14
RNA-binding protein 14

1

8

High-throughput

0.489

High

902890

YTHD1
YTH domain-containing family protein 1

1

5

High-throughput

0.489

High

902891

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

3

High-throughput

0.489

High

902893

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.489

High

67126

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

3

High-throughput

0.479

High

279312

TULP3
Tubby-related protein 3

1

6

High-throughput

0.479

High

549748

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

2

Small-scale

0.479

High

821702

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

2

Small-scale

0.479

High

902829

TRAF3
TNF receptor-associated factor 3

1

17

Small-scale

0.479

High

902846

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

902858

TRM2A
tRNA

1

1

High-throughput

0.479

High

2888

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.470

High

902848

ZMAT1
Zinc finger matrin-type protein 1

1

1

High-throughput

0.439

High

902913

ZBT32
Zinc finger and BTB domain-containing protein 32

1

2

High-throughput

0.439

High

324655

HEXI1
Protein HEXIM1

1

6

High-throughput

0.437

High

612942

EGR1
Early growth response protein 1

1

2

High-throughput

0.437

High

902862

VA0D2
V-type proton ATPase subunit d 2

1

1

High-throughput

0.437

High

902912

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

3

High-throughput

0.437

High

555204

ECP
Eosinophil cationic protein

2

0

High-throughput

0.328

High

902859

SYCP3
Synaptonemal complex protein 3

2

0

High-throughput

0.319

High

902911

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

2

0

High-throughput

0.318

High

339144

TYDP2
Tyrosyl-DNA phosphodiesterase 2

2

0

High-throughput

0.316

High

902900

GAR1
H/ACA ribonucleoprotein complex subunit 1

2

0

High-throughput

0.298

High

225366

ERD23
ER lumen protein-retaining receptor 3

1

0

High-throughput

0.279

Low

298688

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.279

Low

299628

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.279

Low

345165

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

387646

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

547948

UTER
Uteroglobin

1

0

High-throughput

0.279

Low

617490

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

716660

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.279

Low

784554

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

902814

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.279

Low

902815

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.279

Low

902816

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.279

Low

902817

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.279

Low

902822

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.279

Low

902830

CHIT1
Chitotriosidase-1

1

0

High-throughput

0.279

Low

902837

BTG3
Protein BTG3

1

0

High-throughput

0.279

Low

902843

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

902864

CO053
Putative uncharacterized protein encoded by LINC02694

1

0

High-throughput

0.279

Low

902867

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.279

Low

902872

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.279

Low

902877

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.279

Low

902886

EFC11
EF-hand calcium-binding domain-containing protein 11

1

0

High-throughput

0.279

Low

902887

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

902888

CINP
Cyclin-dependent kinase 2-interacting protein

1

0

High-throughput

0.279

Low

902899

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

902905

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

902827

MBTD1
MBT domain-containing protein 1

1

0

High-throughput

0.269

Low

902856

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.269

Low

902901

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.269

Low

902838

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

902915

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.249

Low

902896

XAGE1
X antigen family member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025