HitPredict

Interactor 1: RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Gene: POLR3A

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 456
+	Mm
		70955 B2RXC6_MOUSE (1-1390): 0: 1778: 97.99		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		156082 RPC1_HUMAN (1-1390): 0: 1782: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Mm
		444957 RPB1_MOUSE (2-1382): 0: 1534: 32.10		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		625106 RPB1_HUMAN (2-1382): 0: 1534: 32.10		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		375494 RPB1_YEAST (1-1381): 0: 1438: 31.80		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		375544 RPB1_YEAST (1-1381): 0: 1438: 31.80		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Mm
		192267 RPA1_MOUSE (1136-1366): 1.65e-51: 202: 23.61		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		317188 RPA1_HUMAN (1147-1366): 4.77e-51: 200: 23.87		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		317187 RPA1_HUMAN (1147-1366): 4.77e-51: 200: 23.87		RUVB2_HUMAN (2-455): 0: 651: 42.76