HitPredict

Interactor 1: IFIT3 (O14879)
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)
Gene: IFIT3

Interactor 2: IFIT2 (P09913)
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)
Gene: IFIT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	16189514, 28514442, 33961781, 21642987, 32296183, 31515488
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	TPR_12~TPR_8, TPR_7~TPR_8, TPR_8~TPR_8
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009615 - response to virus GO:0051607 - defense response to virus GO:0140374 - antiviral innate immune response
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 472
+	Hs
		157463 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		Q8IZ03_HUMAN (1-472): 7e-111: 338: 99.58
+	Hs
		157457 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFT1B_HUMAN (1-463): 8.77e-102: 314: 43.88
+	Hs
		157450 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFIT5_HUMAN (1-472): 1.16e-98: 306: 44.91
+	Hs
		157393 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFIT3_HUMAN (1-471): 1.24e-97: 304: 55.93
+	Hs
		456202 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFIT2_HUMAN (1-472): 1.93e-109: 334: 100.00
+	Hs
		456280 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFIT5_HUMAN (1-472): 1.16e-98: 306: 44.91
+	Hs
		157417 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFIT1_HUMAN (14-336): 1.08e-13: 74.9: 11.68
+	Hs
		456283 IFT1B_HUMAN (1-443): 1.23e-90: 286: 45.81		IFIT1_HUMAN (14-336): 1.08e-13: 74.9: 11.68
+	Hs
		174451 OGT1_HUMAN (8-242): 6e-34: 138: 17.45		OGT1_HUMAN (23-298): 3.87e-37: 147: 17.03
+	Hs
		174456 KDM6A_HUMAN (38-401): 7.2e-34: 138: 10.24		OGT1_HUMAN (23-298): 3.87e-37: 147: 17.03
+	At
		1280893 SPY_ARATH (98-480): 3.72e-49: 183: 13.73		SPY_ARATH (20-272): 5.94e-22: 101: 14.08
+	Sc
		743211 CDC27_YEAST (28-320): 1.5e-47: 177: 15.05		CDC27_YEAST (318-471): 4.22e-10: 64.1: 12.96
+	Mm
		1186529 OGT1_MOUSE (8-218): 6.7e-34: 138: 18.96		NPHP3_MOUSE (75-277): 4.2e-12: 70.6: 17.20