HitPredict

Interactor 1: KLF11 (O14901)
Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)
Gene: KLF11

Interactor 2: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.818

Property	Details
Experiments	15300592, 12006497
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~zf-C2H2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0006915 - apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 360
+	Hs
		157869 KLF11_HUMAN (1-512): 3.64e-168: 487: 100.00		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Hs
		563707 ZKSC1_HUMAN (357-489): 1.18e-57: 202: 34.59		MK07_HUMAN (11-355): 3.65e-140: 419: 49.28
+	Hs
		434963 SP1_HUMAN (387-503): 9.79e-34: 137: 55.56		MK01_HUMAN (1-360): 2.42e-158: 449: 100.00
+	Hs
		434957 SP1_HUMAN (387-503): 9.79e-34: 137: 55.56		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Hs
		435106 SP1_HUMAN (387-503): 9.79e-34: 137: 55.56		MK14_HUMAN (18-356): 7.86e-112: 332: 48.97
+	Mm
		292654 SP1_MOUSE (387-503): 1.38e-33: 137: 54.70		MK14_MOUSE (18-356): 3.49e-111: 330: 48.97