HitPredict

Interactor 1: LIN7A (O14910)
Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)
Gene: LIN7A

Interactor 2: PALS2 (Q9NZW5)
Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)
Gene: PALS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	24366813, 32296183, 11311936, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	L27~L27, Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0065003 - protein-containing complex assembly GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 233 Hs			1 540
+	Hs
		1334778 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		PALS2_HUMAN (1-540): 0: 546: 100.00
+	Hs
		158282 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		MPP2_HUMAN (1-540): 2.39e-179: 519: 66.31
+	Hs
		1050415 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		MPP2_HUMAN (1-540): 2.39e-179: 519: 66.31
+	Hs
		158254 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		CSKP_HUMAN (1-540): 9.97e-146: 444: 37.92
+	Hs
		159269 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		CSKP_HUMAN (1-540): 9.97e-146: 444: 37.92
+	Mm
		251089 LIN7B_MOUSE (18-217): 8.75e-52: 168: 77.00		CSKP_MOUSE (1-540): 1.23e-145: 443: 37.92
+	Hs
		158294 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		PALS1_HUMAN (1-539): 7.94e-140: 421: 33.87
+	Mm
		251090 LIN7C_MOUSE (18-211): 1.25e-50: 165: 79.38		CSKP_MOUSE (1-540): 1.23e-145: 443: 37.92
+	Hs
		158288 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		MPP7_HUMAN (1-540): 2.61e-135: 406: 34.74
+	Hs
		158279 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		MPP3_HUMAN (1-539): 7.82e-135: 405: 32.42
+	Hs
		1232501 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		PALS1_HUMAN (1-539): 7.94e-140: 421: 33.87
+	Hs
		1132892 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		MPP7_HUMAN (1-540): 2.61e-135: 406: 34.74
+	Hs
		1032760 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		MPP3_HUMAN (1-539): 7.82e-135: 405: 32.42
+	Hs
		91342 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		E5RI47_HUMAN (1-196): 6.58e-79: 247: 65.31
+	Hs
		91352 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		E5RI47_HUMAN (1-196): 6.58e-79: 247: 65.31
+	Hs
		158271 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		DLG4_HUMAN (88-214): 2.24e-14: 78: 16.42
+	Hs
		158277 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		DLG1_HUMAN (7-214): 3.38e-14: 77.6: 14.91
+	Rn
		677810 LIN7B_RAT (18-214): 2.15e-51: 167: 78.17		DLG4_RAT (88-214): 2.11e-14: 78: 16.42
+	Hs
		942382 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		DLG4_HUMAN (88-214): 2.24e-14: 78: 16.42
+	Hs
		1021563 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		DLG1_HUMAN (7-214): 3.38e-14: 77.6: 14.91