HitPredict - High confidence protein-protein interactions

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.992

Property	Details
Experiments	25486864, 29111346, 30500824, 9346485, 10807933, 11585904, 9914500, 12890679, 9721103, 12709429, 17079871, 17939994, 23792959, 24611898, 24912152, 9891086, 12351658, 21399639, 9520446, 16365431 and 5 others more... 21423167, 23776406, 14743216, 21765415, 16319058
Identification Methods	enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, in-gel kinase assay, protein kinase assay, molecular sieving, cosedimentation in solution, light scattering and 1 others more... tandem affinity purification
Interaction Type	direct interaction, physical association, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	IKBKB_SDD~IKBKB_SDD, IKBKB_SDD~Pkinase, Pkinase~Pkinase
Common GO terms	GO:0002223 - stimulatory C-type lectin receptor signaling pathway GO:0002479 - antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity and 41 others more... GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0006954 - inflammatory response GO:0007249 - canonical NF-kappaB signal transduction GO:0008384 - IkappaB kinase activity GO:0008385 - IkappaB kinase complex GO:0009615 - response to virus GO:0009898 - cytoplasmic side of plasma membrane GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway GO:0018105 - peptidyl-serine phosphorylation GO:0019901 - protein kinase binding GO:0030866 - cortical actin cytoskeleton organization GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0034138 - toll-like receptor 3 signaling pathway GO:0035509 - negative regulation of myosin-light-chain-phosphatase activity GO:0035631 - CD40 receptor complex GO:0035666 - TRIF-dependent toll-like receptor signaling pathway GO:0038095 - Fc-epsilon receptor signaling pathway GO:0042325 - regulation of phosphorylation GO:0042803 - protein homodimerization activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045121 - membrane raft GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0050852 - T cell receptor signaling pathway GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0051403 - stress-activated MAPK cascade GO:0051604 - protein maturation GO:0070498 - interleukin-1-mediated signaling pathway GO:0071356 - cellular response to tumor necrosis factor GO:0072659 - protein localization to plasma membrane GO:0097110 - scaffold protein binding GO:0106310 - protein serine kinase activity GO:1903140 - regulation of establishment of endothelial barrier GO:1903347 - negative regulation of bicellular tight junction assembly GO:1990459 - transferrin receptor binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	756
Hs

1	756

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Last updated: 15 Jul 2024