Protein: COPE
Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)

Gene: COPE, SEC28
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P40509

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005198 - structural molecule activity
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006891 - intra-Golgi vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

825664

COPA
Coatomer subunit alpha

13

1

Small-scale

0.985

High

825652

COPB2
Coatomer subunit beta'

9

1

Small-scale

0.751

High

825655

COPD
Coatomer subunit delta

6

0

Small-scale

0.699

High

732157

COPG
Coatomer subunit gamma

6

0

Small-scale

0.697

High

825651

COPB
Coatomer subunit beta

5

0

Small-scale

0.682

High

825663

COPZ
Coatomer subunit zeta

3

0

High-throughput

0.634

High

825675

ERV41
ER-derived vesicles protein ERV41

2

1

High-throughput

0.611

High

825666

DSL1
Protein transport protein DSL1

3

0

Small-scale

0.601

High

825679

VPS74
Vacuolar protein sorting-associated protein 74

2

0

Small-scale

0.577

High

825648

COPE
Coatomer subunit epsilon

2

0

Small-scale

0.561

High

652928

BET1
Protein transport protein BET1

2

0

Small-scale

0.559

High

801686

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

2

0

Small-scale

0.559

High

536130

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.527

High

392854

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.521

High

510556

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.521

High

579532

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.521

High

670804

SIS1
Protein SIS1

2

1

High-throughput

0.521

High

526882

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.504

High

545149

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.504

High

818948

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.504

High

780081

MNN4
Mannosyltransferase regulator 4

1

0

Small-scale

0.480

High

811540

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

0

Small-scale

0.480

High

825656

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

Small-scale

0.480

High

813900

ERV46
ER-derived vesicles protein ERV46

1

1

High-throughput

0.479

High

798647

SSH1
Sec sixty-one protein homolog

1

1

High-throughput

0.470

High

825660

SEC16
COPII coat assembly protein SEC16

1

0

Small-scale

0.460

High

646246

SEC22
Protein transport protein SEC22

1

0

Small-scale

0.458

High

763912

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

795033

NU170
Nucleoporin NUP170

1

0

High-throughput

0.458

High

795396

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

803079

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.458

High

812376

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

825682

EXP1
ER export of PMA1 protein 1

1

0

High-throughput

0.458

High

825687

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

671649

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.445

High

676063

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

748426

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

779255

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

825668

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.437

High

825670

H3
Histone H3

1

1

High-throughput

0.437

High

592297

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

825654

EMP47
Protein EMP47

1

0

Small-scale

0.426

High

481644

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.407

High

524180

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

741726

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.407

High

816244

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

825669

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

Small-scale

0.391

High

626767

HSP60
Heat shock protein 60, mitochondrial

2

0

High-throughput

0.307

High

796870

GID4
GID complex substrate-recognition subunit 4

2

0

Small-scale

0.305

High

754629

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

0

Small-scale

0.288

High

744867

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.282

High

825665

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

825667

CBK1
Serine/threonine-protein kinase CBK1

1

0

High-throughput

0.279

Low

825671

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.279

Low

825683

MCA1
Metacaspase-1

1

0

Small-scale

0.279

Low

381535

H2B2
Histone H2B.2

1

0

High-throughput

0.269

Low

382149

H4
Histone H4

1

0

High-throughput

0.269

Low

417117

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.269

Low

419762

H2A2
Histone H2A.2

1

0

High-throughput

0.269

Low

448975

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.269

Low

809331

STM1
Suppressor protein STM1

1

0

High-throughput

0.269

Low

818165

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.269

Low

825673

HMO1
High mobility group protein 1

1

0

High-throughput

0.269

Low

825680

CORO
Coronin-like protein

1

0

High-throughput

0.269

Low

509589

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.261

Low

728644

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

0

Small-scale

0.261

Low

794040

KTR3
Probable mannosyltransferase KTR3

1

0

Small-scale

0.261

Low

825650

CDC1
Cell division control protein 1

1

0

Small-scale

0.261

Low

149805

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383738

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433683

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435142

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

436006

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

444545

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.249

Low

455105

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

460347

SYV
Valine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

504253

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

513050

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

674668

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689500

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

699413

CIN8
Kinesin-like protein CIN8

1

0

High-throughput

0.249

Low

707309

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

735342

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

0

High-throughput

0.249

Low

753413

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

764092

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

778368

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

802212

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

804805

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

808834

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

823090

VPS27
Vacuolar protein sorting-associated protein 27

1

0

Small-scale

0.249

Low

825108

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

0

High-throughput

0.249

Low

825649

VID28
GID complex subunit 5

1

0

Small-scale

0.249

Low

825661

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

825672

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

825674

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

825676

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

825677

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

825678

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

825681

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

825684

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.249

Low

825685

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

825686

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

825688

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.249

Low

394631

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

727090

HS104
Heat shock protein 104

1

0

High-throughput

0.232

Low

798054

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.232

Low

810703

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.232

Low

825653

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

825657

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

825658

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

825659

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

825662

RRT6
Regulator of rDNA transcription protein 6

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025