HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: CSF2R (P15509)
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116)
Gene: CSF2RA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.50	0.581

Property	Details
Experiments	12637324, 17952117
Identification Methods	two hybrid, pull down, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 400
+	Hs
		167462 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		CSF2R_HUMAN (11-400): 7.14e-93: 286: 100.00
+	Hs
		158410 IKKB_HUMAN (1-756): 0: 662: 100.00		IL3RB_HUMAN (122-320): 1.39e-10: 65.2: 13.89
+	Hs
		167480 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		EPHA3_HUMAN (7-321): 2.01e-44: 166: 9.88
+	Hs
		1056244 SIK2_HUMAN (6-753): 1.73e-132: 417: 17.45		I13R2_HUMAN (1-357): 3.77e-48: 169: 14.58
+	Mm
		69649 IKKA_MOUSE (1-742): 3.39e-172: 514: 50.20		PTPRS_MOUSE (2-374): 2.9e-10: 64.4: 9.44
+	Hs
		647831 MARK3_HUMAN (8-710): 6.77e-128: 400: 16.53		EPHB2_HUMAN (7-349): 8.18e-47: 173: 10.70
+	Hs
		625528 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		TITIN_HUMAN (1-214): 2.04e-10: 65.2: 12.00
+	Hs
		617030 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		PTPRD_HUMAN (2-375): 8.19e-23: 102: 9.82