Protein: CRNL1
Crooked neck-like protein 1 (Crooked neck homolog) (hCrn)

Gene: CRNL1, CRNKL1
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9BZJ0

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1128108

DHX8
ATP-dependent RNA helicase DHX8

5

20

High-throughput

0.712

High

1419983

PRP19
Pre-mRNA-processing factor 19

4

20

High-throughput

0.699

High

1346920

SNIP1
Smad nuclear-interacting protein 1

4

3

High-throughput

0.694

High

1419984

PPIE
Peptidyl-prolyl cis-trans isomerase E

4

8

High-throughput

0.694

High

1419990

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

2

High-throughput

0.694

High

351352

SYF2
Pre-mRNA-splicing factor SYF2

4

1

High-throughput

0.691

High

485725

RU2A
U2 small nuclear ribonucleoprotein A'

4

11

High-throughput

0.691

High

974040

RUXF
Small nuclear ribonucleoprotein F

3

20

High-throughput

0.675

High

1286218

RALYL
RNA-binding Raly-like protein

3

20

High-throughput

0.667

High

1290705

ZCH18
Zinc finger CCCH domain-containing protein 18

3

10

High-throughput

0.667

High

1410073

USB1
U6 snRNA phosphodiesterase 1

3

1

High-throughput

0.667

High

1412020

WDR83
WD repeat domain-containing protein 83

3

20

High-throughput

0.667

High

1415986

YJU2
Splicing factor YJU2

3

6

High-throughput

0.667

High

973814

RUXE
Small nuclear ribonucleoprotein E

3

6

High-throughput

0.662

High

1356568

CCD12
Coiled-coil domain-containing protein 12

2

3

High-throughput

0.644

High

1404368

CDC5L
Cell division cycle 5-like protein

3

13

High-throughput

0.631

High

222525

PLRG1
Pleiotropic regulator 1

2

20

High-throughput

0.628

High

471918

RU2B
U2 small nuclear ribonucleoprotein B''

2

20

High-throughput

0.628

High

480301

RU1C
U1 small nuclear ribonucleoprotein C

2

3

High-throughput

0.628

High

574462

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

12

High-throughput

0.628

High

991244

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

14

High-throughput

0.628

High

1090293

ELAV2
ELAV-like protein 2

2

12

High-throughput

0.628

High

1419969

PININ
Pinin

2

3

High-throughput

0.628

High

1419977

DJC17
DnaJ homolog subfamily C member 17

2

13

High-throughput

0.628

High

130604

SPT5H
Transcription elongation factor SPT5

2

8

High-throughput

0.611

High

974194

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

1127143

RBM39
RNA-binding protein 39

2

18

High-throughput

0.611

High

1387547

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

20

High-throughput

0.611

High

298071

SPF27
Pre-mRNA-splicing factor SPF27

2

3

High-throughput

0.601

High

462620

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

20

High-throughput

0.601

High

569272

YJU2B
Probable splicing factor YJU2B

2

6

High-throughput

0.601

High

1137507

SUZ12
Polycomb protein SUZ12

2

3

High-throughput

0.601

High

1138609

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

17

High-throughput

0.601

High

129400

MEN1
Menin

2

7

High-throughput

0.584

High

242840

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.584

High

373087

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

1241783

PRP8
Pre-mRNA-processing-splicing factor 8

2

11

High-throughput

0.584

High

1256732

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1371425

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.574

High

1383600

K1143
Uncharacterized protein KIAA1143

2

2

High-throughput

0.574

High

1411282

LZTS2
Leucine zipper putative tumor suppressor 2

2

11

High-throughput

0.574

High

396884

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

415844

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.541

High

74593

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

17

High-throughput

0.536

High

192638

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

256677

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

17

High-throughput

0.536

High

272998

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

286061

SF3B1
Splicing factor 3B subunit 1

1

8

High-throughput

0.536

High

447406

NPM
Nucleophosmin

1

5

High-throughput

0.536

High

478198

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

542200

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.536

High

634616

LMNB1
Lamin-B1

1

7

High-throughput

0.536

High

788187

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

807570

IF4A3
Eukaryotic initiation factor 4A-III

1

13

High-throughput

0.536

High

859441

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.536

High

970089

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.536

High

1016601

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.536

High

1065413

SSRP1
FACT complex subunit SSRP1

1

13

High-throughput

0.536

High

1089538

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.536

High

1099520

SRSF6
Serine/arginine-rich splicing factor 6

1

16

High-throughput

0.536

High

1111249

SNW1
SNW domain-containing protein 1

1

9

High-throughput

0.536

High

1115987

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.536

High

1145354

RNPS1
RNA-binding protein with serine-rich domain 1

1

20

High-throughput

0.536

High

1149184

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.536

High

1160071

SRSF7
Serine/arginine-rich splicing factor 7

1

16

High-throughput

0.536

High

1160282

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

15

High-throughput

0.536

High

1168885

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

9

High-throughput

0.536

High

1360469

PSPC1
Paraspeckle component 1

1

17

High-throughput

0.536

High

1361522

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.536

High

1419971

LN28A
Protein lin-28 homolog A

1

7

High-throughput

0.536

High

1419974

DDX21
Nucleolar RNA helicase 2

1

14

High-throughput

0.536

High

1419978

PUF60
Poly(U)-binding-splicing factor PUF60

1

17

High-throughput

0.536

High

1419981

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

6

High-throughput

0.536

High

1419985

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.536

High

1419987

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

4

High-throughput

0.536

High

1419988

FBX7
F-box only protein 7

1

1

High-throughput

0.536

High

873998

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

1419976

DISC1
Disrupted in schizophrenia 1 protein

2

3

High-throughput

0.516

High

1367742

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.513

High

889498

CLK1
Dual specificity protein kinase CLK1

1

10

High-throughput

0.501

High

718459

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

1348952

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

134858

SAP18
Histone deacetylase complex subunit SAP18

1

2

High-throughput

0.479

High

138304

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

260416

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

285459

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

346292

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

18

High-throughput

0.479

High

386197

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.479

High

401445

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

406613

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.479

High

520352

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

589619

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

607079

CEBPB
CCAAT/enhancer-binding protein beta

1

13

High-throughput

0.479

High

696432

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

730216

1433B
14-3-3 protein beta/alpha

1

11

High-throughput

0.479

High

731592

STIP1
Stress-induced-phosphoprotein 1

1

14

High-throughput

0.479

High

765863

BMI1
Polycomb complex protein BMI-1

1

15

High-throughput

0.479

High

769104

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

800086

COIL
Coilin

1

5

High-throughput

0.479

High

831383

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

879442

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

905113

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

961106

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

1042924

ERCC6
DNA excision repair protein ERCC-6

1

18

Small-scale

0.479

High

1107180

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

High-throughput

0.479

High

1109211

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

13

High-throughput

0.479

High

1132954

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.479

High

1138026

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

1155733

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

High-throughput

0.479

High

1161654

IF16
Gamma-interferon-inducible protein 16

1

7

High-throughput

0.479

High

1201281

EAPP
E2F-associated phosphoprotein

1

2

High-throughput

0.479

High

1276750

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.479

High

1313409

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1314401

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.479

High

1338354

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1352732

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1380651

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1382836

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.479

High

1404745

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1407859

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.479

High

1417043

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

1419973

ANLN
Anillin

1

5

High-throughput

0.479

High

1419975

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1419979

XPO7
Exportin-7

1

8

High-throughput

0.479

High

1419982

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

1419986

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

20

High-throughput

0.479

High

973085

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

71614

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

288760

NPM3
Nucleoplasmin-3

1

5

High-throughput

0.445

High

335505

SLU7
Pre-mRNA-splicing factor SLU7

1

2

High-throughput

0.445

High

430336

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

1066772

NCBP1
Nuclear cap-binding protein subunit 1

1

3

High-throughput

0.445

High

1119294

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1198656

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

1203252

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.445

High

1387402

ESS2
Splicing factor ESS-2 homolog

1

2

High-throughput

0.445

High

1419968

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

11

High-throughput

0.445

High

1419980

DDX41
Probable ATP-dependent RNA helicase DDX41

1

12

High-throughput

0.445

High

1419989

NUB1
NEDD8 ultimate buster 1

1

2

High-throughput

0.445

High

157819

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.437

High

272446

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

318873

RHBT1
Rho-related BTB domain-containing protein 1

1

10

High-throughput

0.437

High

412569

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

574117

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

2

High-throughput

0.437

High

867400

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.437

High

995806

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.437

High

1141918

EEA1
Early endosome antigen 1

1

8

High-throughput

0.437

High

1255420

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

1295550

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.437

High

1418429

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

1419416

RHBT2
Rho-related BTB domain-containing protein 2

1

12

High-throughput

0.437

High

1419970

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

1419972

CASS4
Cas scaffolding protein family member 4

1

5

High-throughput

0.417

High

1227406

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.407

High

1030683

ANK2
Ankyrin-2

1

0

High-throughput

0.279

Low

1364057

NICA
Nicastrin

1

0

High-throughput

0.279

Low

939650

BID
BH3-interacting domain death agonist

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025