HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 32555320, 9751059, 35918322, 20797629, 18519641, 15125833, 19959994, 24618592, 26740240, 25595906, 26802121, 26221961, 18375836, 18202307, 18593939, 15919917, 12624112, 15456896, 15217903, 28214532 and 62 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, protein kinase assay, tandem affinity purification, in-gel kinase assay, surface plasmon resonance, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Pkinase, Ank_5~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007249 - canonical NF-kappaB signal transduction
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 756
Hs

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Last updated: 15 Jul 2024