Protein: CD11B
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)

Gene: CD11B, CDK11B
Organism: Homo sapiens
Interactions: 172
UniProt ID: P21127

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001558 - regulation of cell growth
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625193

CSK22
Casein kinase II subunit alpha'

7

19

High-throughput

0.965

High

636038

CD11B
Cyclin-dependent kinase 11B

5

17

Small-scale

0.918

High

636088

CDC37
Hsp90 co-chaperone Cdc37

4

7

Small-scale

0.903

High

636065

CSK2B
Casein kinase II subunit beta

3

2

High-throughput

0.839

High

461141

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.827

High

636045

CCND3
G1/S-specific cyclin-D3

2

20

Small-scale

0.817

High

636066

CSK21
Casein kinase II subunit alpha

2

19

High-throughput

0.811

High

636077

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

12

High-throughput

0.789

High

636074

PAK1
Serine/threonine-protein kinase PAK 1

2

10

Small-scale

0.786

High

636161

CCNL1
Cyclin-L1

2

20

High-throughput

0.776

High

354902

CHK2
Serine/threonine-protein kinase Chk2

1

15

Small-scale

0.770

High

636052

CDK7
Cyclin-dependent kinase 7

2

18

Small-scale

0.768

High

636084

RNPS1
RNA-binding protein with serine-rich domain 1

2

7

High-throughput

0.759

High

636086

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

2

2

High-throughput

0.705

High

74435

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.691

High

158400

RFXK
DNA-binding protein RFXANK

1

4

High-throughput

0.691

High

636050

MAPK2
MAP kinase-activated protein kinase 2

1

10

High-throughput

0.691

High

636075

SRSF6
Serine/arginine-rich splicing factor 6

1

7

High-throughput

0.691

High

636160

ZN221
Zinc finger protein 221

1

1

High-throughput

0.691

High

636164

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.691

High

331959

KAT7
Histone acetyltransferase KAT7

3

3

Small-scale

0.681

High

636158

S30BP
SAP30-binding protein

3

3

High-throughput

0.667

High

636062

1433E
14-3-3 protein epsilon

3

5

Small-scale

0.660

High

636108

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

2

0

High-throughput

0.649

High

636099

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

7

High-throughput

0.628

High

636063

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

High-throughput

0.621

High

636102

BTNL9
Butyrophilin-like protein 9

1

6

High-throughput

0.618

High

251514

CCNT1
Cyclin-T1

1

20

High-throughput

0.618

High

252230

CCNT2
Cyclin-T2

1

20

High-throughput

0.618

High

400272

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

411342

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

472454

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.618

High

636051

CDK8
Cyclin-dependent kinase 8

1

18

High-throughput

0.618

High

636054

PLK1
Serine/threonine-protein kinase PLK1

1

15

High-throughput

0.618

High

636058

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

9

High-throughput

0.618

High

636092

LARP7
La-related protein 7

1

14

High-throughput

0.618

High

636104

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

636132

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

5

Small-scale

0.618

High

636167

CD11A
Cyclin-dependent kinase 11A

1

18

High-throughput

0.618

High

636081

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

2

High-throughput

0.584

High

636163

ANR50
Ankyrin repeat domain-containing protein 50

1

0

High-throughput

0.578

High

636133

RANB9
Ran-binding protein 9

1

6

Small-scale

0.578

High

636070

BTK
Tyrosine-protein kinase BTK

1

13

High-throughput

0.575

High

636094

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.575

High

636159

DDX41
Probable ATP-dependent RNA helicase DDX41

2

7

High-throughput

0.571

High

131322

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

8

Small-scale

0.565

High

395485

ESR1
Estrogen receptor

1

13

Small-scale

0.561

High

636042

1433T
14-3-3 protein theta

1

20

Small-scale

0.561

High

636046

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.561

High

636061

1433G
14-3-3 protein gamma

1

20

Small-scale

0.561

High

636064

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.561

High

636095

CE170
Centrosomal protein of 170 kDa

1

6

High-throughput

0.553

High

636116

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.553

High

191534

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

521537

H14
Histone H1.4

1

20

High-throughput

0.536

High

636055

ATX1
Ataxin-1

1

4

High-throughput

0.536

High

636068

CYC
Cytochrome c

1

1

High-throughput

0.536

High

636079

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.536

High

636097

RSBN1
Lysine-specific demethylase 9

1

2

High-throughput

0.536

High

636123

EZH1
Histone-lysine N-methyltransferase EZH1

1

4

High-throughput

0.536

High

636126

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

636134

TCPQM
T-complex protein 1 subunit theta-like 2

1

17

High-throughput

0.536

High

636138

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.536

High

636056

FGF8
Fibroblast growth factor 8

1

0

High-throughput

0.513

High

636143

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

636069

H11
Histone H1.1

1

20

Small-scale

0.501

High

636078

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

High-throughput

0.501

High

636144

DNAI2
Dynein axonemal intermediate chain 2

1

11

High-throughput

0.489

High

636149

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.489

High

636041

MOES
Moesin

1

4

High-throughput

0.481

High

81676

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

6

High-throughput

0.479

High

134557

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.479

High

140741

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

187646

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.479

High

187887

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

12

High-throughput

0.479

High

251428

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

1

1

High-throughput

0.479

High

259436

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

316746

MTA2
Metastasis-associated protein MTA2

1

6

High-throughput

0.479

High

320626

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.479

High

331500

SPDEF
SAM pointed domain-containing Ets transcription factor

1

3

Small-scale

0.479

High

352073

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.479

High

371151

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.479

High

413179

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

536486

HSP7C
Heat shock cognate 71 kDa protein

1

9

Small-scale

0.479

High

543458

VDR
Vitamin D3 receptor

1

15

Small-scale

0.479

High

557856

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.479

High

576162

PO2F1
POU domain, class 2, transcription factor 1

1

5

Small-scale

0.479

High

587903

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

615628

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.479

High

636043

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

636047

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

636049

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.479

High

636053

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

636057

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.479

High

636060

DCAF7
DDB1- and CUL4-associated factor 7

1

11

High-throughput

0.479

High

636067

H33
Histone H3.3

1

4

High-throughput

0.479

High

636072

RBBP4
Histone-binding protein RBBP4

1

7

High-throughput

0.479

High

636076

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

8

High-throughput

0.479

High

636082

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

5

High-throughput

0.479

High

636087

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

636089

RBBP7
Histone-binding protein RBBP7

1

12

High-throughput

0.479

High

636090

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

636091

PCGF3
Polycomb group RING finger protein 3

1

14

High-throughput

0.479

High

636100

CDC73
Parafibromin

1

2

High-throughput

0.479

High

636105

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

636106

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

Small-scale

0.479

High

636107

PCGF5
Polycomb group RING finger protein 5

1

13

High-throughput

0.479

High

636109

P66A
Transcriptional repressor p66-alpha

1

1

High-throughput

0.479

High

636110

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

14

High-throughput

0.479

High

636111

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

636112

YAF2
YY1-associated factor 2

1

1

High-throughput

0.479

High

636113

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

6

Small-scale

0.479

High

636115

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.479

High

636117

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

636118

SERB1
SERPINE1 mRNA-binding protein 1

1

6

High-throughput

0.479

High

636119

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

636121

JADE3
Protein Jade-3

1

2

High-throughput

0.479

High

636122

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

636124

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.479

High

636125

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

636127

ARK2N
Protein ARK2N

1

1

High-throughput

0.479

High

636129

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

636130

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

636131

HEXI2
Protein HEXIM2

1

5

High-throughput

0.479

High

636136

RING2
E3 ubiquitin-protein ligase RING2

1

18

High-throughput

0.479

High

636137

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

6

High-throughput

0.479

High

636139

MTA3
Metastasis-associated protein MTA3

1

7

High-throughput

0.479

High

636141

HIRP3
HIRA-interacting protein 3

1

3

High-throughput

0.479

High

636145

SKI8
Superkiller complex protein 8

1

8

High-throughput

0.479

High

636146

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.479

High

636147

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.479

High

636148

ESF1
ESF1 homolog

1

1

High-throughput

0.479

High

636152

NLE1
Notchless protein homolog 1

1

7

High-throughput

0.479

High

636153

GPTC2
G patch domain-containing protein 2

1

3

High-throughput

0.479

High

636154

GPT2L
G patch domain-containing protein 2-like

1

3

High-throughput

0.479

High

636155

TBA8
Tubulin alpha-8 chain

1

6

High-throughput

0.479

High

636157

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

636162

GPTC8
G patch domain-containing protein 8

1

8

High-throughput

0.479

High

636166

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

5

High-throughput

0.479

High

636168

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.479

High

636169

SP16H
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

317511

TPPP
Tubulin polymerization-promoting protein

1

0

High-throughput

0.460

High

636040

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.458

High

636135

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

636150

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

520511

RARA
Retinoic acid receptor alpha

1

12

Small-scale

0.445

High

636080

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

636085

SF01
Splicing factor 1

1

1

High-throughput

0.445

High

636128

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.439

High

636140

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.438

High

636044

PEX2
Peroxisome biogenesis factor 2

1

1

High-throughput

0.437

High

636048

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

636083

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.437

High

636098

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.437

High

636101

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.437

High

636120

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.437

High

636039

SYT1
Synaptotagmin-1

1

0

High-throughput

0.426

High

636093

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

636165

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

125825

AP4M1
AP-4 complex subunit mu-1

1

2

High-throughput

0.407

High

164251

NRP1
Neuropilin-1

1

1

High-throughput

0.407

High

636071

ECHP
Peroxisomal bifunctional enzyme

1

4

High-throughput

0.407

High

636103

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

169179

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

636059

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.279

Low

636073

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

636096

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

636151

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

636156

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

636114

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

636142

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025