HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: EGLN3 (Q9H6Z9)
Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
Gene: EGLN3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	19786027, 23732909
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 239
+	Hs
		167619 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1305592 M3K5_HUMAN (14-657): 9.04e-137: 439: 20.00		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1327876 SIK2_HUMAN (6-753): 1.73e-132: 417: 17.45		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		625601 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1332730 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		625561 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		EGLN2_HUMAN (12-226): 6.89e-132: 379: 61.86
+	Hs
		1326661 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		EGLN1_HUMAN (2-225): 3.05e-143: 409: 64.29