Protein: CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)

Gene: CTDS1, CTDSP1
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9GZU7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006470 - protein dephosphorylation
GO:0008420 - RNA polymerase II CTD heptapeptide repeat phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181733

CTDSL
CTD small phosphatase-like protein

4

7

High-throughput

0.892

High

158591

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

7

High-throughput

0.861

High

388088

MBP
Myelin basic protein

6

2

High-throughput

0.738

High

1405942

CDCA3
Cell division cycle-associated protein 3

10

3

High-throughput

0.692

High

997119

TBA4A
Tubulin alpha-4A chain

3

6

High-throughput

0.667

High

1259487

TBA1A
Tubulin alpha-1A chain

3

6

High-throughput

0.667

High

1428911

TBB1
Tubulin beta-1 chain

3

5

High-throughput

0.667

High

350134

SNAI1
Zinc finger protein SNAI1

2

15

Small-scale

0.653

High

1191969

TBB8
Tubulin beta-8 chain

2

4

High-throughput

0.611

High

246266

MABP1
Mitogen-activated protein kinase-binding protein 1

2

1

High-throughput

0.606

High

440201

LCK
Tyrosine-protein kinase Lck

2

1

High-throughput

0.606

High

842993

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

4

High-throughput

0.606

High

1051418

ZBT16
Zinc finger and BTB domain-containing protein 16

2

13

High-throughput

0.606

High

1061553

ACTN3
Alpha-actinin-3

2

1

High-throughput

0.606

High

978285

RHOB
Rho-related GTP-binding protein RhoB

2

8

High-throughput

0.584

High

140429

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

347918

BAG3
BAG family molecular chaperone regulator 3

2

0

High-throughput

0.580

High

699931

IP3KB
Inositol-trisphosphate 3-kinase B

2

0

High-throughput

0.580

High

977157

YPEL5
Protein yippee-like 5

2

0

High-throughput

0.580

High

1239785

FAP20
Fanconi anemia core complex-associated protein 20

2

0

High-throughput

0.580

High

1244219

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.580

High

1281034

STRA8
Stimulated by retinoic acid gene 8 protein homolog

2

0

High-throughput

0.580

High

1358993

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

1410256

F110A
Protein FAM110A

2

0

High-throughput

0.580

High

1416170

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1428909

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

0

High-throughput

0.580

High

1428919

FANCL
E3 ubiquitin-protein ligase FANCL

2

0

High-throughput

0.580

High

1428921

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

1428913

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

4

Small-scale

0.561

High

1230759

HEAT6
HEAT repeat-containing protein 6

2

1

High-throughput

0.558

High

456155

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

6

High-throughput

0.541

High

641254

FGFR2
Fibroblast growth factor receptor 2

1

8

High-throughput

0.541

High

1053740

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

1

High-throughput

0.541

High

1055091

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

12

High-throughput

0.541

High

1217609

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

3

High-throughput

0.541

High

1428925

PKHM1
Pleckstrin homology domain-containing family M member 1

1

2

High-throughput

0.541

High

173329

XPO1
Exportin-1

1

2

High-throughput

0.536

High

552382

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.536

High

565702

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.536

High

931292

AT12A
Potassium-transporting ATPase alpha chain 2

1

3

High-throughput

0.536

High

1410581

TBA1C
Tubulin alpha-1C chain

1

6

High-throughput

0.536

High

1428914

ABCB6
ATP-binding cassette sub-family B member 6

1

3

High-throughput

0.536

High

1428918

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.536

High

1428920

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

High-throughput

0.536

High

1336468

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.532

High

562813

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

609891

IBP3
Insulin-like growth factor-binding protein 3

1

0

High-throughput

0.513

High

777632

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.513

High

930364

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

941967

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.513

High

1428915

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

0

High-throughput

0.513

High

1428917

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

1428922

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.513

High

1428923

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.513

High

667440

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

7

Small-scale

0.501

High

943620

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

4

High-throughput

0.494

High

1206679

LRC73
Leucine-rich repeat-containing protein 73

1

1

High-throughput

0.494

High

1295374

GPSM1
G-protein-signaling modulator 1

1

1

High-throughput

0.494

High

1324537

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

1

High-throughput

0.494

High

552075

ADT1
ADP/ATP translocase 1

1

4

High-throughput

0.489

High

1272624

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

2

High-throughput

0.489

High

1288657

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

2

High-throughput

0.489

High

1315843

AN13A
Ankyrin repeat domain-containing protein 13A

1

5

High-throughput

0.489

High

1413738

TBCD
Tubulin-specific chaperone D

1

1

High-throughput

0.489

High

1428908

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.489

High

1428910

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.489

High

374184

RASN
GTPase NRas

1

3

High-throughput

0.479

High

374912

RASH
GTPase HRas

1

2

High-throughput

0.479

High

562381

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

581274

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.479

High

953659

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

955564

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

962455

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

988686

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

1015759

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.479

High

1095306

REST
RE1-silencing transcription factor

1

3

Small-scale

0.479

High

1153901

SMAD2
Mothers against decapentaplegic homolog 2

1

6

Small-scale

0.479

High

1154005

SMAD1
Mothers against decapentaplegic homolog 1

1

6

Small-scale

0.479

High

1428912

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.479

High

1165403

Q17RL8
HCG2004980, isoform CRA_e

1

3

High-throughput

0.470

High

1260563

PDZD4
PDZ domain-containing protein 4

1

3

High-throughput

0.439

High

1369903

OSTF1
Osteoclast-stimulating factor 1

1

3

High-throughput

0.439

High

126786

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.437

High

375927

RASK
GTPase KRas

1

3

High-throughput

0.437

High

710473

EPHA2
Ephrin type-A receptor 2

1

5

High-throughput

0.437

High

845793

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.437

High

1428924

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

1411595

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.407

High

1251222

DUSTY
Dual serine/threonine and tyrosine protein kinase

3

0

High-throughput

0.347

High

1409732

F118B
Protein FAM118B

3

0

High-throughput

0.347

High

296002

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.316

High

922368

CRBA2
Beta-crystallin A2

2

0

High-throughput

0.316

High

1279464

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

1288884

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.316

High

1349052

R3GEF
Guanine nucleotide exchange factor for Rab-3A

2

0

High-throughput

0.316

High

67503

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.282

High

260951

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

943126

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

967275

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

1186602

KRA61
Keratin-associated protein 6-1

1

0

High-throughput

0.279

Low

1219181

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.279

Low

1219230

LIPK
Lipase member K

1

0

High-throughput

0.279

Low

1240286

FXL22
F-box and leucine-rich protein 22

1

0

High-throughput

0.279

Low

1357040

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.279

Low

1395645

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

1428916

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

733859

CDD
Cytidine deaminase

1

0

High-throughput

0.232

Low

1363504

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025