HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	11971985, 16051665
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 1424
+	Hs
		167643 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		158486 IKKB_HUMAN (1-756): 0: 662: 100.00		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		158533 IKKB_HUMAN (1-756): 0: 662: 100.00		EPAS1_HUMAN (12-878): 3.88e-100: 343: 13.27
+	Hs
		625469 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		568683 KAPCA_HUMAN (4-283): 2.67e-90: 288: 27.66		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		1075398 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89