Protein: CTDSL
CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)

Gene: CTDSL, CTDSPL
Organism: Homo sapiens
Interactions: 88
UniProt ID: O15194

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0008420 - RNA polymerase II CTD heptapeptide repeat phosphatase activity
GO:0046872 - metal ion binding
GO:0070062 - extracellular exosome
GO:2000134 - negative regulation of G1/S transition of mitotic cell cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181733

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

4

7

High-throughput

0.892

High

181677

MBP
Myelin basic protein

4

2

High-throughput

0.698

High

158536

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

7

High-throughput

0.691

High

181728

CDCA3
Cell division cycle-associated protein 3

6

3

High-throughput

0.673

High

181682

FGFR2
Fibroblast growth factor receptor 2

1

8

High-throughput

0.541

High

181692

MAGA8
Melanoma-associated antigen 8

1

2

High-throughput

0.536

High

181669

TBCD4
TBC1 domain family member 4

1

2

High-throughput

0.489

High

181747

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.489

High

125865

ARVC
Splicing regulator ARVCF

1

5

High-throughput

0.479

High

181670

CTND1
Catenin delta-1

1

3

High-throughput

0.479

High

181675

SNAI1
Zinc finger protein SNAI1

1

15

Small-scale

0.479

High

181676

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

181681

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

4

High-throughput

0.479

High

181683

ITA6
Integrin alpha-6

1

2

High-throughput

0.479

High

181684

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

4

High-throughput

0.479

High

181687

MRP1
Multidrug resistance-associated protein 1

1

1

High-throughput

0.479

High

181689

MERL
Merlin

1

1

High-throughput

0.479

High

181693

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.479

High

181696

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.479

High

181705

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

4

High-throughput

0.479

High

181706

SMAD2
Mothers against decapentaplegic homolog 2

1

6

Small-scale

0.479

High

181707

SMAD1
Mothers against decapentaplegic homolog 1

1

6

Small-scale

0.479

High

181716

UBP31
Ubiquitin carboxyl-terminal hydrolase 31

1

4

High-throughput

0.479

High

181717

MICA3
[F-actin]-monooxygenase MICAL3

1

3

High-throughput

0.479

High

181724

NECT2
Nectin-2

1

4

High-throughput

0.479

High

181732

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

181736

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

4

Small-scale

0.479

High

181739

FMN2
Formin-2

1

3

High-throughput

0.479

High

181667

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.458

High

181671

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

181678

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

181680

CD44
CD44 antigen

1

0

High-throughput

0.458

High

181688

CTNA1
Catenin alpha-1

1

0

High-throughput

0.458

High

181698

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

181704

RFTN1
Raftlin

1

0

High-throughput

0.458

High

181727

NIBA2
Protein Niban 2

1

0

High-throughput

0.458

High

181735

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.458

High

181740

CEIP2
Cell surface hyaluronidase CEMIP2

1

0

High-throughput

0.458

High

181748

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.458

High

48442

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.437

High

174669

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

1

High-throughput

0.437

High

181673

MPZL1
Myelin protein zero-like protein 1

1

2

High-throughput

0.437

High

181674

AGRL2
Adhesion G protein-coupled receptor L2

1

1

High-throughput

0.437

High

181679

ITA5
Integrin alpha-5

1

2

High-throughput

0.437

High

181686

EPHA2
Ephrin type-A receptor 2

1

5

High-throughput

0.437

High

181691

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.437

High

181694

NUMB
Protein numb homolog

1

1

High-throughput

0.437

High

181697

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.437

High

181700

ZO1
Tight junction protein 1

1

1

High-throughput

0.437

High

181702

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

3

High-throughput

0.437

High

181703

S39A6
Zinc transporter ZIP6

1

1

High-throughput

0.437

High

181708

AR13B
ADP-ribosylation factor-like protein 13B

1

5

High-throughput

0.437

High

181709

TB10B
TBC1 domain family member 10B

1

2

High-throughput

0.437

High

181711

F1711
Protein FAM171A1

1

1

High-throughput

0.437

High

181712

DAB2P
Disabled homolog 2-interacting protein

1

1

High-throughput

0.437

High

181713

F171B
Protein FAM171B

1

1

High-throughput

0.437

High

181715

GRIN3
G protein-regulated inducer of neurite outgrowth 3

1

1

High-throughput

0.437

High

181718

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

2

High-throughput

0.437

High

181719

TTC7B
Tetratricopeptide repeat protein 7B

1

1

High-throughput

0.437

High

181725

KIRR1
Kin of IRRE-like protein 1

1

1

High-throughput

0.437

High

181726

CEP89
Centrosomal protein of 89 kDa

1

4

High-throughput

0.437

High

181730

CADM1
Cell adhesion molecule 1

1

3

High-throughput

0.437

High

181734

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.437

High

181737

K1549
UPF0606 protein KIAA1549

1

1

High-throughput

0.437

High

181738

PSD3
PH and SEC7 domain-containing protein 3

1

3

High-throughput

0.437

High

181741

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.437

High

181742

NEB1
Neurabin-1

1

1

High-throughput

0.437

High

181745

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.437

High

181746

S12A7
Solute carrier family 12 member 7

1

1

High-throughput

0.437

High

181750

NUMBL
Numb-like protein

1

1

High-throughput

0.437

High

181668

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

181672

PALM
Paralemmin-1

1

0

High-throughput

0.249

Low

181685

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.249

Low

181690

ADDB
Beta-adducin

1

0

High-throughput

0.249

Low

181695

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.249

Low

181699

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.249

Low

181701

ANK3
Ankyrin-3

1

0

High-throughput

0.249

Low

181710

CAHD1
VWFA and cache domain-containing protein 1

1

0

High-throughput

0.249

Low

181714

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

High-throughput

0.249

Low

181720

RELL1
RELT-like protein 1

1

0

High-throughput

0.249

Low

181721

MALD2
MARVEL domain-containing protein 2

1

0

High-throughput

0.249

Low

181722

CNNM3
Metal transporter CNNM3

1

0

High-throughput

0.249

Low

181723

C2C4C
C2 calcium-dependent domain-containing protein 4C

1

0

High-throughput

0.249

Low

181729

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.249

Low

181731

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.249

Low

181743

EFR3B
Protein EFR3 homolog B

1

0

High-throughput

0.249

Low

181744

DTNA
Dystrobrevin alpha

1

0

High-throughput

0.249

Low

181749

ROBO1
Roundabout homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025