Protein: RHG39
Rho GTPase-activating protein 39

Gene: RHG39, ARHGAP39
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q9C0H5

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955562

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

988685

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

High-throughput

0.768

High

978283

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

222196

NCK2
Cytoplasmic protein NCK2

1

19

High-throughput

0.691

High

956229

RAB4B
Ras-related protein Rab-4B

1

7

High-throughput

0.691

High

1243430

CNKR3
Connector enhancer of kinase suppressor of ras 3

4

2

High-throughput

0.691

High

1409750

SPI2B
Spindlin-2B

3

0

High-throughput

0.638

High

126785

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

375924

RASK
GTPase KRas

1

13

High-throughput

0.618

High

463753

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.618

High

466446

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581273

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

953658

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962452

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

1015756

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1421263

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1421264

TANC2
Protein TANC2

3

5

High-throughput

0.593

High

137481

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

2

1

High-throughput

0.571

High

396898

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

1314692

SRRM1
Serine/arginine repetitive matrix protein 1

2

4

High-throughput

0.571

High

1360878

CNKR2
Connector enhancer of kinase suppressor of ras 2

2

12

High-throughput

0.571

High

1421262

PEAK1
Inactive tyrosine-protein kinase PEAK1

2

7

High-throughput

0.571

High

257961

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

2

0

High-throughput

0.547

High

1405991

C10
Protein C10

2

0

High-throughput

0.547

High

1421267

LYAR
Cell growth-regulating nucleolar protein

2

0

High-throughput

0.547

High

282486

KTNA1
Katanin p60 ATPase-containing subunit A1

1

5

High-throughput

0.536

High

553063

PIP
Prolactin-inducible protein

1

1

High-throughput

0.536

High

611330

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.536

High

625606

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.536

High

683512

IKBA
NF-kappa-B inhibitor alpha

1

8

High-throughput

0.536

High

1421261

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

189066

NCAM2
Neural cell adhesion molecule 2

2

8

High-throughput

0.521

High

724180

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

2

1

High-throughput

0.521

High

1347545

SMRC2
SWI/SNF complex subunit SMARCC2

2

6

High-throughput

0.521

High

535514

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.515

High

1120581

LRP8
Low-density lipoprotein receptor-related protein 8

1

0

High-throughput

0.513

High

1421274

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

1421272

PCDBF
Protocadherin beta-15

1

2

High-throughput

0.489

High

141091

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

165409

PSA7
Proteasome subunit alpha type-7

1

3

High-throughput

0.479

High

181732

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.479

High

299364

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

417736

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

424459

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.479

High

451068

LDHB
L-lactate dehydrogenase B chain

1

3

High-throughput

0.479

High

452394

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.479

High

471235

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

484640

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

551244

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.479

High

553276

KCRB
Creatine kinase B-type

1

2

High-throughput

0.479

High

647651

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

4

High-throughput

0.479

High

656233

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.479

High

670000

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.479

High

681015

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

698018

CALR
Calreticulin

1

3

High-throughput

0.479

High

701076

PSB6
Proteasome subunit beta type-6

1

2

High-throughput

0.479

High

710657

EPHA3
Ephrin type-A receptor 3

1

10

High-throughput

0.479

High

715762

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

716619

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

6

High-throughput

0.479

High

717595

PDIA3
Protein disulfide-isomerase A3

1

6

High-throughput

0.479

High

717985

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.479

High

731597

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

732397

PRDX2
Peroxiredoxin-2

1

6

High-throughput

0.479

High

761018

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

813493

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

High-throughput

0.479

High

881095

NASP
Nuclear autoantigenic sperm protein

1

2

High-throughput

0.479

High

895961

F10A1
Hsc70-interacting protein

1

4

High-throughput

0.479

High

905116

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

915486

HMGA2
High mobility group protein HMGI-C

1

1

High-throughput

0.479

High

936444

AFAD
Afadin

1

7

High-throughput

0.479

High

949204

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.479

High

954901

PSA6
Proteasome subunit alpha type-6

1

3

High-throughput

0.479

High

1038696

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

2

High-throughput

0.479

High

1058639

CKAP4
Cytoskeleton-associated protein 4

1

12

High-throughput

0.479

High

1097047

PRDX4
Peroxiredoxin-4

1

6

High-throughput

0.479

High

1117141

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.479

High

1147422

EPHA7
Ephrin type-A receptor 7

1

9

High-throughput

0.479

High

1157917

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.479

High

1353267

PARD3
Partitioning defective 3 homolog

1

5

High-throughput

0.479

High

1367210

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1396802

SNX27
Sorting nexin-27

1

10

High-throughput

0.479

High

1421259

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1421260

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1421265

WDR6
tRNA

1

6

High-throughput

0.479

High

1421266

GID8
Glucose-induced degradation protein 8 homolog

1

2

High-throughput

0.479

High

1421268

ANFY1
Rabankyrin-5

1

8

High-throughput

0.479

High

1421269

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.479

High

359733

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

443099

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

447856

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.458

High

814573

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

869973

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

1147269

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1156414

SEPT7
Septin-7

1

0

High-throughput

0.458

High

1421270

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

1421273

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

932130

EPHA4
Ephrin type-A receptor 4

1

11

High-throughput

0.457

High

255204

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

229811

CALU
Calumenin

1

9

High-throughput

0.437

High

522493

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.437

High

571514

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.437

High

643058

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.437

High

931892

EPHA5
Ephrin type-A receptor 5

1

13

High-throughput

0.437

High

932939

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

4

High-throughput

0.437

High

963014

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.437

High

1041266

CAV1
Caveolin-1

1

3

High-throughput

0.437

High

1131382

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.437

High

1145679

RCN1
Reticulocalbin-1

1

7

High-throughput

0.437

High

1159831

OCLN
Occludin

1

2

High-throughput

0.437

High

1421271

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.437

High

271177

COBL
Protein cordon-bleu

2

0

High-throughput

0.298

High


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Last updated: 11Aug2025