HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12525502
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0043130 - ubiquitin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 618
+	Hs
		849322 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		1206094 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		849363 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		849321 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		159050 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Mm
		620834 UB2D1_MOUSE (2-149): 1.04e-75: 223: 38.93		MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21
+	Hs
		963034 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		849309 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		919708 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		849400 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		BIRC7_HUMAN (299-618): 4.32e-34: 133: 20.94
+	Hs
		849456 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		BIRC6_HUMAN (34-167): 3.57e-31: 132: 19.42
+	Hs
		957802 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		849308 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		919707 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		1298970 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		BIRC8_HUMAN (43-167): 1.67e-30: 121: 30.95
+	Hs
		849413 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		BIRC8_HUMAN (43-167): 1.67e-30: 121: 30.95
+	Hs
		1264347 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		MYLIP_HUMAN (558-617): 3.91e-22: 101: 41.67
+	Hs
		849386 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		MYLIP_HUMAN (558-617): 3.91e-22: 101: 41.67
+	Hs
		849387 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RFFL_HUMAN (567-618): 2.51e-17: 85.8: 42.31
+	Hs
		849396 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		MIB2_HUMAN (558-617): 3.21e-10: 65.3: 36.67