Protein: CDC45
Cell division control protein 45 homolog (PORC-PI-1)

Gene: CDC45
Organism: Homo sapiens
Interactions: 120
UniProt ID: O75419

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000727 - double-strand break repair via break-induced replication
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

264230

SLD5
DNA replication complex GINS protein SLD5

5

3

Small-scale

0.918

High

264189

MCM2
DNA replication licensing factor MCM2

5

14

Small-scale

0.914

High

264178

MCM7
DNA replication licensing factor MCM7

4

17

Small-scale

0.878

High

264171

MCM3
DNA replication licensing factor MCM3

3

18

Small-scale

0.829

High

264202

MCM6
DNA replication licensing factor MCM6

3

18

Small-scale

0.828

High

264203

PSF1
DNA replication complex GINS protein PSF1

2

3

Small-scale

0.798

High

264231

PSF3
DNA replication complex GINS protein PSF3

2

2

Small-scale

0.789

High

264252

PSF2
DNA replication complex GINS protein PSF2

2

3

Small-scale

0.789

High

264176

MCM4
DNA replication licensing factor MCM4

2

14

Small-scale

0.754

High

264225

TOPB1
DNA topoisomerase 2-binding protein 1

3

1

Small-scale

0.670

High

264208

CEP55
Centrosomal protein of 55 kDa

4

0

High-throughput

0.668

High

264169

RFA2
Replication protein A 32 kDa subunit

4

0

Small-scale

0.657

High

264237

CLSPN
Claspin

3

0

Small-scale

0.652

High

264152

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

1

Small-scale

0.618

High

264177

MCM5
DNA replication licensing factor MCM5

1

16

Small-scale

0.618

High

264201

CUL3
Cullin-3

2

1

High-throughput

0.611

High

264249

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.580

High

264154

RECQ4
ATP-dependent DNA helicase Q4

2

0

Small-scale

0.559

High

264185

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

217218

ORC5
Origin recognition complex subunit 5

1

1

High-throughput

0.536

High

264172

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.536

High

264214

MCM10
Protein MCM10 homolog

1

2

High-throughput

0.536

High

264159

S100B
Protein S100-B

1

1

High-throughput

0.536

High

264233

TIPIN
TIMELESS-interacting protein

1

1

High-throughput

0.536

High

264250

TIM
Protein timeless homolog

1

1

High-throughput

0.536

High

264254

T22D4
TSC22 domain family protein 4

1

1

High-throughput

0.536

High

264183

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

264187

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

264246

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.513

High

182303

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.513

High

264158

ALBU
Albumin

1

0

High-throughput

0.513

High

264188

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

264192

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.513

High

264210

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

264220

ARI1B
AT-rich interactive domain-containing protein 1B

1

0

High-throughput

0.513

High

264228

NACC1
Nucleus accumbens-associated protein 1

1

0

High-throughput

0.513

High

264240

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

0

Small-scale

0.513

High

264255

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

Small-scale

0.513

High

264256

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

134814

IMA3
Importin subunit alpha-3

1

2

High-throughput

0.501

High

264163

DPOLA
DNA polymerase alpha catalytic subunit

1

4

Small-scale

0.501

High

208963

NCK2
Cytoplasmic protein NCK2

1

3

High-throughput

0.489

High

243220

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.489

High

264166

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

High-throughput

0.489

High

264175

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

264184

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

1

High-throughput

0.489

High

264191

BLK
Tyrosine-protein kinase Blk

1

2

High-throughput

0.489

High

264196

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

1

High-throughput

0.489

High

264197

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.489

High

264251

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.489

High

264164

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

69186

IMA8
Importin subunit alpha-8

1

2

High-throughput

0.479

High

154106

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

226053

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

264170

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.479

High

264173

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

264190

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

264204

KS6A1
Ribosomal protein S6 kinase alpha-1

1

1

High-throughput

0.479

High

264205

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.479

High

264207

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.479

High

264248

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

High-throughput

0.479

High

264258

DUS10
Dual specificity protein phosphatase 10

1

1

High-throughput

0.479

High

264244

DONS
Protein downstream neighbor of Son

1

0

Small-scale

0.464

High

264198

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.460

High

264199

ORC2
Origin recognition complex subunit 2

1

0

Small-scale

0.460

High

264257

ORC6
Origin recognition complex subunit 6

1

0

Small-scale

0.460

High

243701

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

264156

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

264165

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

264179

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

264180

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

264193

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.458

High

264195

H31
Histone H3.1

1

0

Small-scale

0.458

High

264209

ESCO2
N-acetyltransferase ESCO2

1

0

Small-scale

0.458

High

264215

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

264217

FANCM
Fanconi anemia group M protein

1

0

Small-scale

0.458

High

264224

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

Small-scale

0.458

High

264234

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

264236

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

264238

SHCAF
SIN3-HDAC complex-associated factor

1

0

Small-scale

0.458

High

264241

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

264242

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

264245

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

264161

LCK
Tyrosine-protein kinase Lck

1

1

Small-scale

0.457

High

264186

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.457

High

264174

DPOD1
DNA polymerase delta catalytic subunit

1

4

Small-scale

0.445

High

264200

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

264211

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.407

High

264194

RAB4B
Ras-related protein Rab-4B

2

0

High-throughput

0.316

High

208695

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.282

High

264227

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

1

0

High-throughput

0.282

High

171902

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

217290

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

245291

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

264162

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

264168

ARSA
Arylsulfatase A

1

0

High-throughput

0.279

Low

264181

BASI
Basigin

1

0

High-throughput

0.279

Low

264182

FDFT
Squalene synthase

1

0

High-throughput

0.279

Low

264213

LYPD5
Ly6/PLAUR domain-containing protein 5

1

0

High-throughput

0.279

Low

264216

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

264218

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

264222

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

264223

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

264229

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.279

Low

264232

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

264243

MTMR4
Myotubularin-related protein 4

1

0

High-throughput

0.279

Low

264247

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.279

Low

264226

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

264153

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

264155

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

264160

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

264167

CCL2
C-C motif chemokine 2

1

0

Small-scale

0.249

Low

264206

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

264212

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

264219

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

264221

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.249

Low

264235

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

264239

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

264253

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

264157

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024