HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 1992
+	Hs
		1056647 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		TRIPC_HUMAN (1-1992): 0: 1579: 100.00
+	Hs
		849331 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		TRIPC_HUMAN (1-1992): 0: 1579: 100.00
+	Hs
		125000 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		159084 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		159085 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NED4L_HUMAN (989-1990): 0: 588: 16.37
+	Hs
		125808 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		125262 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		1294888 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		849411 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		849416 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NED4L_HUMAN (989-1990): 0: 588: 16.37
+	Hs
		159031 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Hs
		159074 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HERC6_HUMAN (1084-1989): 4.71e-161: 524: 15.39
+	Hs
		849444 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		808052 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Hs
		159052 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		UBE3A_HUMAN (1492-1991): 2.41e-140: 462: 27.02
+	Hs
		849311 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBE3A_HUMAN (1492-1991): 2.41e-140: 462: 27.02
+	Hs
		1357018 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Hs
		159070 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72
+	Hs
		849334 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBE3C_HUMAN (1697-1992): 3.54e-26: 119: 30.57
+	Hs
		849353 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72