HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: MYCN (P04198)
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
Gene: MYCN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	unassigned3713
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 926 Hs			1 464
+	Hs
		159129 CSKP_HUMAN (1-926): 0: 973: 100.00		MYC_HUMAN (7-463): 5.91e-69: 228: 34.16
+	Hs
		159146 CSKP_HUMAN (1-926): 0: 973: 100.00		MYCL_HUMAN (19-463): 1.22e-34: 134: 25.28
+	Hs
		379539 MARK2_HUMAN (4-680): 5.16e-140: 438: 18.64		MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00
+	Hs
		379041 MARK3_HUMAN (4-669): 7.23e-139: 434: 19.62		MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00
+	Hs
		347313 PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84		MYC_HUMAN (7-463): 5.91e-69: 228: 34.16
+	Hs
		347148 MARK2_HUMAN (4-680): 5.16e-140: 438: 18.64		MYC_HUMAN (7-463): 5.91e-69: 228: 34.16
+	Hs
		380030 KCC2A_HUMAN (8-312): 6.34e-85: 282: 46.08		MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00
+	Hs
		252905 MARK3_HUMAN (4-669): 7.23e-139: 434: 19.62		MITF_HUMAN (65-462): 8.44e-27: 114: 13.27
+	Hs
		346720 KCC2D_HUMAN (8-312): 3.56e-88: 291: 47.71		MYC_HUMAN (7-463): 5.91e-69: 228: 34.16
+	Hs
		346719 KCC2G_HUMAN (8-312): 4.57e-83: 280: 46.08		MYC_HUMAN (7-463): 5.91e-69: 228: 34.16
+	Dm
		959131 KCC2A_DROME (8-319): 1.39e-83: 280: 45.22		MYC_DROME (210-462): 2.89e-27: 117: 17.12