HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007155 - cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Hs			1 192
+	Hs
		159153 CSKP_HUMAN (1-926): 0: 973: 100.00		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		159149 CSKP_HUMAN (1-926): 0: 973: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		159267 CSKP_HUMAN (1-926): 0: 973: 100.00		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		159192 CSKP_HUMAN (1-926): 0: 973: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		159184 CSKP_HUMAN (1-926): 0: 973: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		925239 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564500 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Mm
		925797 DLG4_MOUSE (402-922): 5.68e-145: 449: 22.37		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Hs
		545346 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		1021562 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Mm
		1111996 DLG4_MOUSE (402-922): 5.68e-145: 449: 22.37		Q3TLP8_MOUSE (1-192): 1.17e-81: 242: 90.52
+	Hs
		545425 MPP7_HUMAN (354-926): 1.78e-145: 445: 30.81		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		892341 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950954 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894207 PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		893948 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900683 PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		900424 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436278 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		436349 MPP7_HUMAN (354-926): 1.78e-145: 445: 30.81		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45