HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.864

The method score is based on:

Property Details
Experiments 32707033, 35914814, 21763699
Identification Methods affinity chromatography technology, two hybrid, two hybrid fragment pooling approach, pull down, blue native page
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Guanylate_kin~PDZ, PDZ~PDZ, PH~Pkinase, PDZ~SH3_2
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 926
Hs

1 1591
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024