Protein: CSKP
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)

Gene: CSKP, CASK
Organism: Homo sapiens
Interactions: 210
UniProt ID: O14936

Gene Ontology (top 5):
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0004385 - GMP kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005102 - signaling receptor binding
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168680

DLG1
Disks large homolog 1

7

16

Small-scale

0.972

High

167670

LIN7A
Protein lin-7 homolog A

7

20

Small-scale

0.970

High

168758

LIN7C
Protein lin-7 homolog C

6

20

Small-scale

0.947

High

168750

LIN7B
Protein lin-7 homolog B

5

20

Small-scale

0.926

High

168749

SH24A
SH2 domain-containing protein 4A

4

12

High-throughput

0.911

High

168732

ARHGQ
Rho guanine nucleotide exchange factor 26

4

19

High-throughput

0.881

High

168683

SNTB2
Beta-2-syntrophin

3

20

High-throughput

0.867

High

168681

TIAM1
Rho guanine nucleotide exchange factor TIAM1

3

18

Small-scale

0.864

High

58685

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

3

13

High-throughput

0.861

High

168674

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

3

20

Small-scale

0.853

High

168728

CSKI1
Caskin-1

2

10

Small-scale

0.828

High

168596

PRKN
E3 ubiquitin-protein ligase parkin

2

14

Small-scale

0.806

High

168778

DUS10
Dual specificity protein phosphatase 10

2

6

High-throughput

0.789

High

168777

JAM1
Junctional adhesion molecule A

2

13

Small-scale

0.777

High

168747

DNJC5
DnaJ homolog subfamily C member 5

2

8

High-throughput

0.768

High

168607

RASK
GTPase KRas

2

20

High-throughput

0.754

High

168668

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

69744

ZN785
Zinc finger protein 785

2

3

High-throughput

0.726

High

168670

DLG4
Disks large homolog 4

1

15

Small-scale

0.713

High

168671

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.710

High

60823

MBPHL
Myosin-binding protein H-like

2

9

High-throughput

0.705

High

168653

CDK9
Cyclin-dependent kinase 9

1

11

High-throughput

0.698

High

168655

DUS3
Dual specificity protein phosphatase 3

1

5

High-throughput

0.698

High

168759

PLK2
Serine/threonine-protein kinase PLK2

1

20

High-throughput

0.698

High

168616

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.691

High

168687

SNTB1
Beta-1-syntrophin

1

20

High-throughput

0.691

High

168730

DLG3
Disks large homolog 3

1

15

High-throughput

0.691

High

168740

EFC11
EF-hand calcium-binding domain-containing protein 11

1

18

High-throughput

0.691

High

168736

ERBIN
Erbin

1

15

Small-scale

0.681

High

168679

EPS8
Epidermal growth factor receptor kinase substrate 8

1

10

Small-scale

0.665

High

168700

TBR1
T-box brain protein 1

3

1

Small-scale

0.658

High

168742

KPCD2
Serine/threonine-protein kinase D2

1

20

High-throughput

0.656

High

168603

FCSD2
F-BAR and double SH3 domains protein 2

1

5

Small-scale

0.647

High

168618

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.647

High

168625

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.647

High

168763

WHRN
Whirlin

1

20

Small-scale

0.647

High

168619

TAU
Microtubule-associated protein tau

3

20

High-throughput

0.641

High

168701

KI26B
Kinesin-like protein KIF26B

2

20

High-throughput

0.628

High

168772

SPAT2
Spermatogenesis-associated protein 2

2

2

High-throughput

0.628

High

168649

KPCI
Protein kinase C iota type

1

20

High-throughput

0.621

High

168658

RBM5
RNA-binding protein 5

1

1

High-throughput

0.621

High

168714

MARK2
Serine/threonine-protein kinase MARK2

1

13

High-throughput

0.621

High

168727

PAR3L
Partitioning defective 3 homolog B

1

20

High-throughput

0.621

High

168734

RBM14
RNA-binding protein 14

1

2

High-throughput

0.621

High

168741

PAR6G
Partitioning defective 6 homolog gamma

1

18

High-throughput

0.621

High

168641

SDC2
Syndecan-2

2

1

Small-scale

0.620

High

168636

APC
Adenomatous polyposis coli protein

2

16

High-throughput

0.619

High

126365

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

168597

KIF1B
Kinesin-like protein KIF1B

1

20

High-throughput

0.618

High

168602

RNF8
E3 ubiquitin-protein ligase RNF8

1

9

Small-scale

0.618

High

168612

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

168615

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

168622

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

168627

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

168631

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

168639

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

168644

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

14

High-throughput

0.618

High

168647

CCNF
Cyclin-F

1

2

High-throughput

0.618

High

168650

MUC18
Cell surface glycoprotein MUC18

1

13

High-throughput

0.618

High

168657

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

168659

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

168663

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

13

High-throughput

0.618

High

168664

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

168669

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

168672

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

168689

ARHG7
Rho guanine nucleotide exchange factor 7

1

8

Small-scale

0.618

High

168692

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.618

High

168694

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

168697

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

168710

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

168715

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

168748

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

168752

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

168771

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

168691

PCM1
Pericentriolar material 1 protein

2

1

High-throughput

0.613

High

159116

ABLM1
Actin-binding LIM protein 1

2

5

High-throughput

0.611

High

168599

DTNB
Dystrobrevin beta

2

13

High-throughput

0.611

High

168751

NET4
Netrin-4

2

4

High-throughput

0.606

High

168766

MLX
Max-like protein X

2

10

High-throughput

0.606

High

168606

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.595

High

168621

LAMP1
Lysosome-associated membrane glycoprotein 1

2

11

High-throughput

0.584

High

168652

KCNJ4
Inward rectifier potassium channel 4

2

20

Small-scale

0.584

High

168690

KCJ12
ATP-sensitive inward rectifier potassium channel 12

2

20

Small-scale

0.584

High

168585

CSKP
Peripheral plasma membrane protein CASK

1

16

Small-scale

0.575

High

168609

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.575

High

168611

MAS
Proto-oncogene Mas

1

11

Small-scale

0.575

High

168637

ADA1D
Alpha-1D adrenergic receptor

1

16

Small-scale

0.575

High

168707

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

168756

CLTR2
Cysteinyl leukotriene receptor 2

1

20

Small-scale

0.575

High

168624

MYCL
Protein L-Myc

2

11

High-throughput

0.574

High

168648

ID1
DNA-binding protein inhibitor ID-1

1

1

Small-scale

0.573

High

168608

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

168743

CNTP4
Contactin-associated protein-like 4

1

19

Small-scale

0.561

High

168768

CNTP2
Contactin-associated protein-like 2

1

18

Small-scale

0.561

High

168673

RBM10
RNA-binding protein 10

1

1

High-throughput

0.555

High

168660

AF17
Protein AF-17

1

1

High-throughput

0.541

High

168661

SYMC
Methionine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.541

High

168662

WNT7B
Protein Wnt-7b

1

1

High-throughput

0.541

High

168720

TRI22
E3 ubiquitin-protein ligase TRIM22

1

7

High-throughput

0.541

High

168620

EPB41
Protein 4.1

1

20

Small-scale

0.536

High

168589

MOT7
Monocarboxylate transporter 7

1

5

High-throughput

0.536

High

168600

SURF6
Surfeit locus protein 6

1

4

High-throughput

0.536

High

168614

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

16

High-throughput

0.536

High

168623

DMD
Dystrophin

1

18

High-throughput

0.536

High

168634

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

20

High-throughput

0.536

High

168640

KINH
Kinesin-1 heavy chain

1

18

High-throughput

0.536

High

168651

UTRN
Utrophin

1

19

High-throughput

0.536

High

168678

TRI26
Tripartite motif-containing protein 26

1

6

High-throughput

0.536

High

168709

FXL19
F-box/LRR-repeat protein 19

1

1

High-throughput

0.536

High

168724

EIF1A
Probable RNA-binding protein EIF1AD

1

2

High-throughput

0.536

High

168753

E41L5
Band 4.1-like protein 5

1

20

High-throughput

0.536

High

168755

TULP4
Tubby-related protein 4

1

3

High-throughput

0.536

High

168765

CTNL1
Alpha-catulin

1

3

High-throughput

0.536

High

168767

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

5

High-throughput

0.536

High

168770

KI26A
Kinesin-like protein KIF26A

1

14

High-throughput

0.536

High

168773

DLGP4
Disks large-associated protein 4

1

20

High-throughput

0.536

High

168775

DTNA
Dystrobrevin alpha

1

13

High-throughput

0.536

High

168629

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.535

High

168774

RP3A
Rabphilin-3A

1

2

Small-scale

0.535

High

168746

TSYL2
Testis-specific Y-encoded-like protein 2

1

0

Small-scale

0.529

High

168643

PGH2
Prostaglandin G/H synthase 2

1

0

High-throughput

0.518

High

168682

I15RA
Interleukin-15 receptor subunit alpha

1

0

High-throughput

0.518

High

168688

IL18
Interleukin-18

1

0

High-throughput

0.518

High

168706

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.518

High

168729

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

168737

P2RX7
P2X purinoceptor 7

1

0

High-throughput

0.518

High

168703

RBG1L
Rab GTPase-activating protein 1-like

1

5

High-throughput

0.514

High

168630

ANFB
Natriuretic peptides B

1

0

High-throughput

0.513

High

168645

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

160944

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

17

Small-scale

0.501

High

168586

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

Small-scale

0.501

High

168610

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.501

High

168613

P53
Cellular tumor antigen p53

1

1

High-throughput

0.501

High

168633

SDC1
Syndecan-1

1

4

Small-scale

0.501

High

168635

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

11

Small-scale

0.501

High

137299

ELL2
RNA polymerase II elongation factor ELL2

1

7

High-throughput

0.494

High

168646

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

3

High-throughput

0.489

High

168702

DB136
Defensin beta 136

1

1

High-throughput

0.489

High

122669

KIF2A
Kinesin-like protein KIF2A

1

18

High-throughput

0.481

High

168594

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.481

High

168666

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.481

High

168676

FMR1
Fragile X messenger ribonucleoprotein 1

1

20

High-throughput

0.481

High

168693

PCBP2
Poly(rC)-binding protein 2

1

6

High-throughput

0.481

High

168695

MARE2
Microtubule-associated protein RP/EB family member 2

1

4

High-throughput

0.481

High

168696

MED1
Mediator of RNA polymerase II transcription subunit 1

1

8

High-throughput

0.481

High

168698

MARE1
Microtubule-associated protein RP/EB family member 1

1

4

High-throughput

0.481

High

168716

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

7

High-throughput

0.481

High

168738

PKP2
Plakophilin-2

1

18

High-throughput

0.481

High

168739

AKAP9
A-kinase anchor protein 9

1

4

High-throughput

0.481

High

168744

NDEL1
Nuclear distribution protein nudE-like 1

1

6

High-throughput

0.481

High

168757

KLC4
Kinesin light chain 4

1

8

High-throughput

0.481

High

168760

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.481

High

168587

PER2
Period circadian protein homolog 2

1

0

High-throughput

0.480

High

168588

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.480

High

125077

LEG9
Galectin-9

1

3

High-throughput

0.479

High

168591

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.479

High

168593

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

168598

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

168601

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

168604

KLHL2
Kelch-like protein 2

1

4

High-throughput

0.479

High

168617

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

168628

EZRI
Ezrin

1

20

High-throughput

0.479

High

168632

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.479

High

168654

R144A
E3 ubiquitin-protein ligase RNF144A

1

5

Small-scale

0.479

High

168656

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

168665

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

168667

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

168675

CAV1
Caveolin-1

1

8

High-throughput

0.479

High

168686

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

5

High-throughput

0.479

High

168699

OCLN
Occludin

1

5

High-throughput

0.479

High

168705

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

168711

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.479

High

168712

FRMD7
FERM domain-containing protein 7

1

20

Small-scale

0.479

High

168717

TMM17
Transmembrane protein 17

1

5

High-throughput

0.479

High

168719

CUL9
Cullin-9

1

8

High-throughput

0.479

High

168722

ARL14
ADP-ribosylation factor-like protein 14

1

11

High-throughput

0.479

High

168725

NEDD1
Protein NEDD1

1

2

High-throughput

0.479

High

168754

E41LA
Band 4.1-like protein 4A

1

20

High-throughput

0.479

High

168762

DLGP2
Disks large-associated protein 2

1

20

High-throughput

0.479

High

168776

ARI1
E3 ubiquitin-protein ligase ARIH1

1

16

Small-scale

0.479

High

168592

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.460

High

168726

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.460

High

168764

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.460

High

168626

EF2
Elongation factor 2

1

0

High-throughput

0.458

High

168761

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

168677

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.457

High

168590

MOT4
Monocarboxylate transporter 4

1

5

High-throughput

0.445

High

168685

TBB3
Tubulin beta-3 chain

1

10

High-throughput

0.445

High

168713

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.445

High

168721

LAT4
Large neutral amino acids transporter small subunit 4

1

2

High-throughput

0.445

High

168769

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.445

High

104845

APRIO
Alternative prion protein

1

11

High-throughput

0.437

High

139762

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

4

High-throughput

0.437

High

168638

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

168642

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

168731

CK052
Uncharacterized protein C11orf52

1

6

High-throughput

0.437

High

4749

A0A1B0GTN4
DLG associated protein 2

1

20

High-throughput

0.407

High

94296

D6R9G5
Kelch like family member 2

1

8

High-throughput

0.407

High

168733

ZN414
Zinc finger protein 414

2

0

High-throughput

0.328

High

168745

CMIP1
Ciliary microtubule inner protein 1

2

0

High-throughput

0.316

High

168595

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.282

High

168605

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.282

High

168704

PXDC1
PX domain-containing protein 1

1

0

High-throughput

0.279

Low

168718

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

168723

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

168735

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.279

Low

168684

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.251

Low

85216

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

168708

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025