HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: MYO6 (Q9UM54)
Unconventional myosin-VI (Unconventional myosin-6)
Gene: MYO6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005938 - cell cortex GO:0045177 - apical part of cell GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 172 Hs			1 1294
+	Hs
		483966 CALM1_HUMAN (20-93): 8.65e-10: 56: 24.36		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		484047 CALM2_HUMAN (20-93): 8.65e-10: 56: 24.36		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Ss
		94703 F2Z5G3_PIG (20-93): 8.65e-10: 56: 24.36		MYO6_PIG (1-1294): 0: 1015: 89.18
+	Hs
		648611 CALL3_HUMAN (32-93): 8.36e-11: 58.6: 25.76		MYO10_HUMAN (3-997): 0: 878: 30.44
+	Hs
		484202 CALM3_HUMAN (20-93): 8.65e-10: 56: 24.36		MYO10_HUMAN (3-997): 0: 878: 30.44
+	Hs
		159549 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		159550 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH10_HUMAN (762-1135): 7.28e-10: 65.8: 15.54
+	Hs
		159551 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH11_HUMAN (844-1177): 1.17e-09: 65.5: 18.55
+	Hs
		624341 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		159640 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYO5A_HUMAN (595-1063): 4.98e-09: 63: 10.72
+	Hs
		624342 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYH10_HUMAN (762-1135): 7.28e-10: 65.8: 15.54
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-172): 7.34e-67: 203: 97.67		MYH10_MOUSE (762-1135): 6.81e-09: 62.8: 16.00
+	Hs
		580614 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		580615 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH10_HUMAN (762-1135): 7.28e-10: 65.8: 15.54
+	Hs
		580616 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH11_HUMAN (844-1177): 1.17e-09: 65.5: 18.55
+	Hs
		501117 MLRV_HUMAN (9-166): 1.98e-54: 171: 57.23		MYO5B_HUMAN (1016-1294): 4.73e-09: 63.4: 12.41
+	Hs
		501118 MLRV_HUMAN (9-166): 1.98e-54: 171: 57.23		MYO5A_HUMAN (595-1063): 4.98e-09: 63: 10.72
+	Hs
		484206 CALM3_HUMAN (20-93): 8.65e-10: 56: 24.36		MYO5C_HUMAN (772-1230): 2.22e-24: 113: 9.42
+	Hs
		648467 CALL3_HUMAN (32-93): 8.36e-11: 58.6: 25.76		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		484218 CALM3_HUMAN (20-93): 8.65e-10: 56: 24.36		MYO5B_HUMAN (1016-1294): 4.73e-09: 63.4: 12.41