HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 802
+	Hs
		159885 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR2_HUMAN (4-797): 0: 737: 56.44
+	Hs
		159889 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR3_HUMAN (5-799): 0: 712: 61.07
+	Hs
		159864 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		159898 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA3_HUMAN (4-778): 0: 595: 18.34
+	Hs
		160004 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA7_HUMAN (4-781): 0: 584: 19.90
+	Hs
		159938 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA4_HUMAN (4-776): 0: 582: 19.47
+	Hs
		159937 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA5_HUMAN (4-771): 0: 580: 18.81
+	Hs
		159897 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		160216 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA6_HUMAN (4-767): 0: 565: 19.93
+	Hs
		159900 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHB2_HUMAN (4-779): 0: 557: 17.27
+	Hs
		159899 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA8_HUMAN (4-763): 0: 549: 19.79
+	Hs
		160015 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK2_HUMAN (114-757): 9.58e-166: 502: 25.84
+	Hs
		160014 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24
+	Rn
		1144355 HGS_RAT (1-777): 3.19e-100: 328: 93.44		NTRK2_RAT (122-757): 1.27e-165: 501: 26.62
+	Hs
		159837 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Mm
		546322 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		NTRK2_MOUSE (122-757): 5e-166: 503: 26.62
+	Hs
		159848 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		241132 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		276985 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		159845 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		CSF1R_HUMAN (33-405): 1.65e-12: 73.2: 15.41