Protein: DVL1
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)

Gene: DVL1
Organism: Homo sapiens
Interactions: 131
UniProt ID: O14640

Gene Ontology (top 5):
GO:0001947 - heart looping
GO:0003151 - outflow tract morphogenesis
GO:0005109 - frizzled binding
GO:0005829 - cytosol
GO:0005874 - microtubule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

159290

DVL2
Segment polarity protein dishevelled homolog DVL-2

7

14

Small-scale

0.954

High

159384

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

15

Small-scale

0.828

High

159293

AXIN1
Axin-1

3

17

Small-scale

0.827

High

159299

FZD7
Frizzled-7

1

20

Small-scale

0.724

High

159387

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.698

High

159289

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

14

Small-scale

0.690

High

159336

DAB2
Disabled homolog 2

1

20

Small-scale

0.647

High

159330

KC1E
Casein kinase I isoform epsilon

2

20

Small-scale

0.643

High

159358

KLH12
Kelch-like protein 12

2

8

Small-scale

0.629

High

159391

SIPA1
Signal-induced proliferation-associated protein 1

1

14

High-throughput

0.621

High

159362

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.618

High

159373

ARHGJ
Rho guanine nucleotide exchange factor 19

1

16

Small-scale

0.618

High

159374

AHI1
Jouberin

1

14

High-throughput

0.618

High

159376

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.618

High

159377

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.618

High

159379

PARD3
Partitioning defective 3 homolog

1

19

High-throughput

0.618

High

159382

ARHG2
Rho guanine nucleotide exchange factor 2

1

20

Small-scale

0.618

High

159389

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.618

High

159411

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.618

High

159396

WWTR1
WW domain-containing transcription regulator protein 1

2

20

Small-scale

0.612

High

159314

ANXA7
Annexin A7

1

3

High-throughput

0.587

High

159322

SYUA
Alpha-synuclein

2

6

High-throughput

0.586

High

159303

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

159315

APC
Adenomatous polyposis coli protein

2

20

Small-scale

0.584

High

159363

RNF43
E3 ubiquitin-protein ligase RNF43

2

7

Small-scale

0.584

High

159402

WWOX
WW domain-containing oxidoreductase

2

3

High-throughput

0.584

High

159341

EPS8
Epidermal growth factor receptor kinase substrate 8

1

18

Small-scale

0.573

High

159360

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

Small-scale

0.573

High

159365

SCYL2
SCY1-like protein 2

1

9

Small-scale

0.561

High

159301

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

6

High-throughput

0.553

High

159339

TLE2
Transducin-like enhancer protein 2

1

13

High-throughput

0.553

High

159368

HECW1
E3 ubiquitin-protein ligase HECW1

1

20

Small-scale

0.552

High

159296

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

20

High-throughput

0.541

High

159308

RB
Retinoblastoma-associated protein

1

3

High-throughput

0.541

High

159383

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

5

High-throughput

0.541

High

66469

RASFA
Ras association domain-containing protein 10

1

8

High-throughput

0.536

High

159300

RASF9
Ras association domain-containing protein 9

1

12

High-throughput

0.536

High

159331

PLK1
Serine/threonine-protein kinase PLK1

1

15

High-throughput

0.536

High

159355

ZNF74
Zinc finger protein 74

1

6

High-throughput

0.536

High

159401

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

1

High-throughput

0.536

High

159390

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

Small-scale

0.534

High

159364

NXN
Nucleoredoxin

1

5

High-throughput

0.515

High

159385

NKD2
Protein naked cuticle homolog 2

1

10

Small-scale

0.515

High

159292

SMAD7
Mothers against decapentaplegic homolog 7

1

16

Small-scale

0.501

High

159309

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

8

Small-scale

0.501

High

159326

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

Small-scale

0.501

High

159335

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.501

High

159344

SMAD4
Mothers against decapentaplegic homolog 4

1

17

Small-scale

0.501

High

159353

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.501

High

159354

SMAD1
Mothers against decapentaplegic homolog 1

1

16

Small-scale

0.501

High

159404

DAPLE
Protein Daple

1

20

Small-scale

0.501

High

159295

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.481

High

159304

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.481

High

159316

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.481

High

159371

TRI69
E3 ubiquitin-protein ligase TRIM69

1

3

High-throughput

0.481

High

122440

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

2

High-throughput

0.479

High

131571

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.479

High

159291

XPO1
Exportin-1

1

7

High-throughput

0.479

High

159297

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

159298

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

13

High-throughput

0.479

High

159305

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.479

High

159307

K2C8
Keratin, type II cytoskeletal 8

1

4

High-throughput

0.479

High

159310

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.479

High

159312

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.479

High

159313

CXA1
Gap junction alpha-1 protein

1

9

High-throughput

0.479

High

159319

CTNA1
Catenin alpha-1

1

9

High-throughput

0.479

High

159320

CTNB1
Catenin beta-1

1

18

Small-scale

0.479

High

159323

CETN2
Centrin-2

1

1

High-throughput

0.479

High

159325

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

11

High-throughput

0.479

High

159327

KC1D
Casein kinase I isoform delta

1

14

Small-scale

0.479

High

159328

PAXI
Paxillin

1

10

High-throughput

0.479

High

159329

ARRB1
Beta-arrestin-1

1

8

Small-scale

0.479

High

159333

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

9

High-throughput

0.479

High

159334

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.479

High

159338

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

159343

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

159345

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

159346

CUL3
Cullin-3

1

7

High-throughput

0.479

High

159347

TFDP1
Transcription factor Dp-1

1

2

Small-scale

0.479

High

159348

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.479

High

159349

FLNC
Filamin-C

1

20

High-throughput

0.479

High

159350

NUMA1
Nuclear mitotic apparatus protein 1

1

16

Small-scale

0.479

High

159351

KS6A2
Ribosomal protein S6 kinase alpha-2

1

13

High-throughput

0.479

High

159356

OCLN
Occludin

1

7

High-throughput

0.479

High

159357

MOONR
Protein moonraker

1

1

High-throughput

0.479

High

159361

CP135
Centrosomal protein of 135 kDa

1

19

High-throughput

0.479

High

159366

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

159370

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

Small-scale

0.479

High

159392

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.479

High

159393

CEP19
Centrosomal protein of 19 kDa

1

3

High-throughput

0.479

High

159395

CEP44
Centrosomal protein of 44 kDa

1

2

High-throughput

0.479

High

159397

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

20

Small-scale

0.479

High

159399

MLXPL
Carbohydrate-responsive element-binding protein

1

9

Small-scale

0.479

High

159400

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

Small-scale

0.479

High

159405

ANFY1
Rabankyrin-5

1

9

High-throughput

0.479

High

159407

RCOR1
REST corepressor 1

1

3

High-throughput

0.479

High

159408

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

8

Small-scale

0.479

High

159410

MARE3
Microtubule-associated protein RP/EB family member 3

1

2

High-throughput

0.479

High

159413

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

2

High-throughput

0.479

High

159414

DAAM1
Disheveled-associated activator of morphogenesis 1

1

6

Small-scale

0.479

High

159415

CEP83
Centrosomal protein of 83 kDa

1

20

High-throughput

0.479

High

159294

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.458

High

159302

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

159369

DET1
DET1 homolog

1

0

High-throughput

0.458

High

159378

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

159381

FRAT1
Proto-oncogene FRAT1

1

0

Small-scale

0.458

High

159394

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

159340

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.445

High

159359

KLH22
Kelch-like protein 22

1

7

High-throughput

0.445

High

159332

ATN1
Atrophin-1

1

7

Small-scale

0.439

High

159375

SMYD1
Histone-lysine N-methyltransferase SMYD1

1

1

High-throughput

0.439

High

159306

TOP3B
DNA topoisomerase 3-beta-1

1

2

High-throughput

0.437

High

159311

IFM1
Interferon-induced transmembrane protein 1

1

4

High-throughput

0.437

High

159317

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

159321

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

159337

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.437

High

159342

RFA4
Replication protein A 30 kDa subunit

1

10

High-throughput

0.437

High

159367

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.437

High

159372

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

159386

NKD1
Protein naked cuticle homolog 1

1

10

Small-scale

0.437

High

159388

PF21A
PHD finger protein 21A

1

8

High-throughput

0.437

High

159398

E41LA
Band 4.1-like protein 4A

1

20

High-throughput

0.437

High

159403

SEP10
Septin-10

1

12

High-throughput

0.437

High

159409

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.437

High

159412

ADIP
Afadin- and alpha-actinin-binding protein

1

5

High-throughput

0.437

High

159380

DCAF4
DDB1- and CUL4-associated factor 4

2

0

High-throughput

0.305

High

159324

MSH2
DNA mismatch repair protein Msh2

1

0

High-throughput

0.282

High

159406

MLH3
DNA mismatch repair protein Mlh3

1

0

High-throughput

0.282

High

159318

SDC4
Syndecan-4

1

0

Small-scale

0.249

Low

159352

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025