HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 32989298, 18773538, 18615013
Identification Methods affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
and 19 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 403
Hs

1 603
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Last updated: 15 Jul 2024