Protein: MED19
Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19)

Gene: MED19
Organism: Homo sapiens
Interactions: 178
UniProt ID: A0JLT2

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

48591

MED14
Mediator of RNA polymerase II transcription subunit 14

8

1

Small-scale

0.970

High

48718

MED10
Mediator of RNA polymerase II transcription subunit 10

11

0

Small-scale

0.929

High

48590

MED7
Mediator of RNA polymerase II transcription subunit 7

9

0

Small-scale

0.925

High

48755

MED31
Mediator of RNA polymerase II transcription subunit 31

10

1

Small-scale

0.760

High

48634

CDK8
Cyclin-dependent kinase 8

11

2

Small-scale

0.758

High

48671

MED1
Mediator of RNA polymerase II transcription subunit 1

11

1

Small-scale

0.758

High

48711

MED8
Mediator of RNA polymerase II transcription subunit 8

10

1

Small-scale

0.758

High

48742

MED13
Mediator of RNA polymerase II transcription subunit 13

10

1

Small-scale

0.756

High

48706

MED12
Mediator of RNA polymerase II transcription subunit 12

9

1

Small-scale

0.754

High

48721

CDK19
Cyclin-dependent kinase 19

9

2

Small-scale

0.753

High

48689

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

7

1

High-throughput

0.750

High

48714

MED15
Mediator of RNA polymerase II transcription subunit 15

7

1

High-throughput

0.750

High

48617

CCNC
Cyclin-C

8

1

Small-scale

0.749

High

48736

MED29
Mediator of RNA polymerase II transcription subunit 29

10

0

Small-scale

0.726

High

48734

MED17
Mediator of RNA polymerase II transcription subunit 17

10

0

Small-scale

0.726

High

48730

MED4
Mediator of RNA polymerase II transcription subunit 4

10

0

Small-scale

0.726

High

48719

MED18
Mediator of RNA polymerase II transcription subunit 18

10

0

Small-scale

0.726

High

48594

MED6
Mediator of RNA polymerase II transcription subunit 6

10

0

Small-scale

0.725

High

48728

MED20
Mediator of RNA polymerase II transcription subunit 20

9

0

Small-scale

0.724

High

48737

MED11
Mediator of RNA polymerase II transcription subunit 11

9

0

Small-scale

0.724

High

48686

MED27
Mediator of RNA polymerase II transcription subunit 27

9

0

Small-scale

0.722

High

48599

MED26
Mediator of RNA polymerase II transcription subunit 26

10

0

Small-scale

0.722

High

48723

MED28
Mediator of RNA polymerase II transcription subunit 28

9

0

Small-scale

0.722

High

48735

MED9
Mediator of RNA polymerase II transcription subunit 9

8

0

Small-scale

0.722

High

48659

MED21
Mediator of RNA polymerase II transcription subunit 21

8

0

Small-scale

0.721

High

48712

MED30
Mediator of RNA polymerase II transcription subunit 30

8

0

Small-scale

0.720

High

48748

MED23
Mediator of RNA polymerase II transcription subunit 23

8

0

Small-scale

0.720

High

48752

MED16
Mediator of RNA polymerase II transcription subunit 16

8

0

Small-scale

0.720

High

48695

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

5

1

High-throughput

0.718

High

48618

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

0

High-throughput

0.718

High

48690

MED25
Mediator of RNA polymerase II transcription subunit 25

8

0

Small-scale

0.718

High

48670

MED22
Mediator of RNA polymerase II transcription subunit 22

8

0

Small-scale

0.717

High

48593

MED24
Mediator of RNA polymerase II transcription subunit 24

7

0

Small-scale

0.715

High

48589

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

0

High-throughput

0.674

High

48615

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

0

High-throughput

0.674

High

48614

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

High-throughput

0.670

High

48624

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

0

High-throughput

0.670

High

48580

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

Small-scale

0.667

High

48628

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

0

High-throughput

0.638

High

48640

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

0

High-throughput

0.638

High

48641

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.638

High

48644

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

0

High-throughput

0.638

High

48647

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

0

High-throughput

0.638

High

48648

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

0

High-throughput

0.638

High

48642

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

3

0

High-throughput

0.628

High

48696

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.606

High

48687

FXL19
F-box/LRR-repeat protein 19

2

0

High-throughput

0.602

High

48584

ELL2
RNA polymerase II elongation factor ELL2

2

1

High-throughput

0.601

High

48592

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

48627

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

48649

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.580

High

48654

RIPP1
Protein ripply1

2

0

High-throughput

0.580

High

48663

CASL
Enhancer of filamentation 1

2

0

High-throughput

0.580

High

48694

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

48604

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

48655

TADBP
TAR DNA-binding protein 43

2

0

High-throughput

0.563

High

48596

UBR5
E3 ubiquitin-protein ligase UBR5

2

0

High-throughput

0.547

High

48740

AFF4
AF4/FMR2 family member 4

2

0

High-throughput

0.547

High

48623

MSX1
Homeobox protein MSX-1

1

1

High-throughput

0.541

High

48620

IKBA
NF-kappa-B inhibitor alpha

1

0

High-throughput

0.518

High

48622

DCK
Deoxycytidine kinase

1

0

High-throughput

0.518

High

48583

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.513

High

48631

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

48652

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

48653

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

48656

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

48672

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.513

High

48676

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.513

High

48685

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

48693

TAD2B
Transcriptional adapter 2-beta

1

0

High-throughput

0.513

High

48708

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

48710

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.513

High

48729

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.513

High

48756

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

48612

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.493

High

48666

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.493

High

48698

LMO3
LIM domain only protein 3

1

0

High-throughput

0.493

High

48705

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

48606

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

48611

GATA1
Erythroid transcription factor

1

0

Small-scale

0.479

High

48619

BRD2
Bromodomain-containing protein 2

1

3

High-throughput

0.479

High

48667

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.479

High

48673

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

48674

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

48679

BRDT
Bromodomain testis-specific protein

1

3

High-throughput

0.479

High

48697

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

48597

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

48600

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

48605

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

48608

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

48633

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

48680

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

48681

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

48688

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

48707

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

48725

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

48727

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

48731

ANLN
Anillin

1

0

High-throughput

0.458

High

48739

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

48581

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

2

High-throughput

0.445

High

48582

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

48585

NOP56
Nucleolar protein 56

1

1

High-throughput

0.445

High

48629

GRP75
Stress-70 protein, mitochondrial

1

1

High-throughput

0.445

High

48658

TCOF
Treacle protein

1

1

High-throughput

0.445

High

48660

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

1

High-throughput

0.445

High

48661

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.445

High

48664

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

High-throughput

0.445

High

48701

ELYS
Protein ELYS

1

1

High-throughput

0.445

High

48726

DDX31
ATP-dependent DNA helicase DDX31

1

1

High-throughput

0.445

High

48732

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.445

High

48741

DDX20
Probable ATP-dependent RNA helicase DDX20

1

1

High-throughput

0.445

High

48747

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.445

High

48751

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.445

High

48753

NOP58
Nucleolar protein 58

1

1

High-throughput

0.445

High

48704

OSTF1
Osteoclast-stimulating factor 1

1

1

High-throughput

0.439

High

48713

RADIL
Ras-associating and dilute domain-containing protein

1

1

High-throughput

0.439

High

48684

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

0

High-throughput

0.438

High

48749

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

48586

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.426

High

48588

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.426

High

48598

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.426

High

48602

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.426

High

48607

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

48613

UBF1
Nucleolar transcription factor 1

1

0

High-throughput

0.426

High

48616

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.426

High

48621

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.426

High

48625

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.426

High

48626

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.426

High

48630

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

0

High-throughput

0.426

High

48632

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.426

High

48637

HCFC1
Host cell factor 1

1

0

High-throughput

0.426

High

48638

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.426

High

48639

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.426

High

48646

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.426

High

48650

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.426

High

48651

SRSF3
Serine/arginine-rich splicing factor 3

1

0

High-throughput

0.426

High

48657

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.426

High

48662

RBM39
RNA-binding protein 39

1

0

High-throughput

0.426

High

48665

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.426

High

48668

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.426

High

48669

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.426

High

48675

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.426

High

48677

SMN
Survival motor neuron protein

1

0

High-throughput

0.426

High

48678

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.426

High

48700

IPO4
Importin-4

1

0

High-throughput

0.426

High

48709

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.426

High

48716

CMS1
Protein CMSS1

1

0

High-throughput

0.426

High

48717

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.426

High

48720

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.426

High

48722

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.426

High

48724

PININ
Pinin

1

0

High-throughput

0.426

High

48733

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.426

High

48738

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.426

High

48744

CDC23
Cell division cycle protein 23 homolog

1

0

High-throughput

0.426

High

48745

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.426

High

48746

ANC2
Anaphase-promoting complex subunit 2

1

0

High-throughput

0.426

High

48750

RUVB1
RuvB-like 1

1

0

High-throughput

0.426

High

48754

ZN281
Zinc finger protein 281

1

0

High-throughput

0.426

High

48691

Q75LH2
Uncharacterized protein FLJ10324

1

1

High-throughput

0.417

High

48595

RL1D1
Ribosomal L1 domain-containing protein 1

1

2

High-throughput

0.407

High

48715

DDX50
ATP-dependent RNA helicase DDX50

1

2

High-throughput

0.407

High

48636

BPL1
Biotin--protein ligase

2

0

High-throughput

0.316

High

48682

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.316

High

48743

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

48645

1433G
14-3-3 protein gamma

1

0

High-throughput

0.268

Low

48603

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

48683

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

48587

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.232

Low

48601

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.232

Low

48609

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

48610

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.232

Low

48635

DYN2
Dynamin-2

1

0

High-throughput

0.232

Low

48643

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.232

Low

48692

NOL8
Nucleolar protein 8

1

0

High-throughput

0.232

Low

48699

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.232

Low

48702

TITIN
Titin

1

0

High-throughput

0.232

Low

48703

GCN1
Stalled ribosome sensor GCN1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024