HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: TBA1C (Q9BQE3)
Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]
Gene: TUBA1C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23443559
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000278 - mitotic cell cycle GO:0005634 - nucleus GO:0015630 - microtubule cytoskeleton GO:0051301 - cell division
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 449
+	Hs
		160334 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		160504 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		969108 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		933175 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		681913 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Hs
		1292191 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		428148 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		933762 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		933569 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		428041 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		681781 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		1175096 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Hs
		428362 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		128991 PLK4_HUMAN (130-391): 1.82e-53: 192: 37.74		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Dm
		332649 PLK4_DROME (130-383): 1.33e-54: 194: 38.91		TBA1_DROME (1-439): 0: 714: 97.27