Protein: LRP6
Low-density lipoprotein receptor-related protein 6 (LRP-6)

Gene: LRP6
Organism: Homo sapiens
Interactions: 124
UniProt ID: O75581

Gene Ontology (top 5):
GO:0005041 - low-density lipoprotein particle receptor activity
GO:0005102 - signaling receptor binding
GO:0005109 - frizzled binding
GO:0005576 - extracellular region
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270322

SOST
Sclerostin

5

6

Small-scale

0.927

High

270244

LRP6
Low-density lipoprotein receptor-related protein 6

3

9

Small-scale

0.847

High

59822

PRS37
Probable inactive serine protease 37

2

20

High-throughput

0.811

High

270350

KLK5
Kallikrein-5

2

12

High-throughput

0.811

High

270245

DKK1
Dickkopf-related protein 1

7

8

Small-scale

0.754

High

170585

AXIN1
Axin-1

8

5

Small-scale

0.746

High

270271

ETV6
Transcription factor ETV6

4

2

High-throughput

0.696

High

158878

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.691

High

257242

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

5

High-throughput

0.691

High

270253

KLK3
Prostate-specific antigen

1

16

High-throughput

0.691

High

270254

CATG
Cathepsin G

1

14

High-throughput

0.691

High

270259

HGF
Hepatocyte growth factor

1

8

High-throughput

0.691

High

270263

KLK2
Kallikrein-2

1

18

High-throughput

0.691

High

270267

CMA1
Chymase

1

16

High-throughput

0.691

High

270283

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

3

High-throughput

0.691

High

270326

SIRPD
Signal-regulatory protein delta

1

2

High-throughput

0.691

High

270327

KLK15
Kallikrein-15

1

12

High-throughput

0.691

High

270345

BTNL2
Butyrophilin-like protein 2

1

1

High-throughput

0.691

High

270280

WNT3A
Protein Wnt-3a

4

13

Small-scale

0.689

High

270276

GSK3B
Glycogen synthase kinase-3 beta

3

3

Small-scale

0.685

High

270306

CHST9
Carbohydrate sulfotransferase 9

3

1

High-throughput

0.667

High

270313

PAR16
Protein mono-ADP-ribosyltransferase PARP16

3

1

High-throughput

0.667

High

270319

RHES
GTP-binding protein Rhes

3

6

High-throughput

0.667

High

270289

CAV1
Caveolin-1

3

2

Small-scale

0.650

High

270275

GSK3A
Glycogen synthase kinase-3 alpha

2

3

Small-scale

0.649

High

270269

PEDF
Pigment epithelium-derived factor

1

2

Small-scale

0.647

High

270321

KREM1
Kremen protein 1

1

8

Small-scale

0.647

High

270330

SG196
Protein O-mannose kinase

4

1

High-throughput

0.638

High

270274

KC1A
Casein kinase I isoform alpha

2

4

High-throughput

0.628

High

270346

DKKL1
Dickkopf-like protein 1

2

1

High-throughput

0.628

High

270344

DKK2
Dickkopf-related protein 2

2

8

Small-scale

0.619

High

258281

LRP5
Low-density lipoprotein receptor-related protein 5

1

9

Small-scale

0.618

High

270296

TAZ
Tafazzin

3

5

High-throughput

0.609

High

270335

RASF1
Ras association domain-containing protein 1

3

1

High-throughput

0.609

High

270299

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

Small-scale

0.601

High

270268

CTNB1
Catenin beta-1

2

3

Small-scale

0.601

High

270328

FZD8
Frizzled-8

2

4

Small-scale

0.595

High

270286

RHOB
Rho-related GTP-binding protein RhoB

2

13

High-throughput

0.584

High

270343

CKLF
Chemokine-like factor

2

0

High-throughput

0.580

High

270348

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

2

0

Small-scale

0.576

High

270248

SG1D1
Secretoglobin family 1D member 1

2

3

High-throughput

0.574

High

270310

TF2LY
Homeobox protein TGIF2LY

2

1

High-throughput

0.574

High

270325

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

8

High-throughput

0.574

High

270342

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

2

High-throughput

0.574

High

135520

WN10B
Protein Wnt-10b

1

13

High-throughput

0.536

High

270247

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

270256

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

270257

PRG2
Bone marrow proteoglycan

1

5

High-throughput

0.536

High

270258

EDN3
Endothelin-3

1

3

High-throughput

0.536

High

270262

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

270288

IL5RA
Interleukin-5 receptor subunit alpha

1

6

High-throughput

0.536

High

270290

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

5

High-throughput

0.536

High

270291

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

4

High-throughput

0.536

High

270298

NMS
Neuromedin-S

1

2

High-throughput

0.536

High

270303

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.536

High

270308

SYT9
Synaptotagmin-9

1

3

High-throughput

0.536

High

270311

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.536

High

270314

KC1AL
Casein kinase I isoform alpha-like

1

4

High-throughput

0.536

High

270316

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

5

High-throughput

0.536

High

270317

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.536

High

270332

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

270336

CBLN4
Cerebellin-4

1

4

High-throughput

0.536

High

270341

P2RX2
P2X purinoceptor 2

1

1

High-throughput

0.536

High

270347

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

8

High-throughput

0.536

High

270349

PRG3
Proteoglycan 3

1

5

High-throughput

0.536

High

270334

AT132
Polyamine-transporting ATPase 13A2

1

0

Small-scale

0.518

High

270255

PGFRB
Platelet-derived growth factor receptor beta

1

4

Small-scale

0.515

High

270287

DAB2
Disabled homolog 2

1

20

Small-scale

0.515

High

270302

CAPR2
Caprin-2

1

4

Small-scale

0.515

High

201506

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

270294

TLR1
Toll-like receptor 1

1

0

High-throughput

0.513

High

270318

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

270353

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

270251

APOB
Apolipoprotein B-100

1

2

Small-scale

0.501

High

270252

WNT1
Proto-oncogene Wnt-1

1

13

Small-scale

0.501

High

270264

MK
Midkine

1

5

Small-scale

0.501

High

270279

WNT3
Proto-oncogene Wnt-3

1

13

Small-scale

0.501

High

242955

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.493

High

180112

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

211336

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.489

High

270246

CCN6
Cellular communication network factor 6

1

4

High-throughput

0.489

High

270260

CRIS2
Cysteine-rich secretory protein 2

1

5

High-throughput

0.489

High

270278

FCGRN
IgG receptor FcRn large subunit p51

1

5

High-throughput

0.489

High

270295

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

9

High-throughput

0.489

High

270307

PODN
Podocan

1

2

High-throughput

0.489

High

270312

TAFA2
Chemokine-like protein TAFA-2

1

8

High-throughput

0.489

High

270315

ZN383
Zinc finger protein 383

1

11

High-throughput

0.489

High

270323

OVOL2
Transcription factor Ovo-like 2

1

19

High-throughput

0.489

High

270333

B3GA2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

1

2

High-throughput

0.489

High

270337

GPTC2
G patch domain-containing protein 2

1

1

High-throughput

0.489

High

270340

DNM3B
DNA

1

1

High-throughput

0.489

High

167783

NPC1
NPC intracellular cholesterol transporter 1

1

2

Small-scale

0.479

High

204829

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

270249

RASN
GTPase NRas

1

12

High-throughput

0.479

High

270250

RASK
GTPase KRas

1

12

High-throughput

0.479

High

270261

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

270265

CCL1
C-C motif chemokine 1

1

2

Small-scale

0.479

High

270266

IBP4
Insulin-like growth factor-binding protein 4

1

4

Small-scale

0.479

High

270272

WNT5A
Protein Wnt-5a

1

13

Small-scale

0.479

High

270277

PAR2
Proteinase-activated receptor 2

1

1

Small-scale

0.479

High

270282

ANTR2
Anthrax toxin receptor 2

1

2

Small-scale

0.479

High

270284

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

270285

RAC3
Ras-related C3 botulinum toxin substrate 3

1

12

High-throughput

0.479

High

270293

FZD5
Frizzled-5

1

4

Small-scale

0.479

High

270324

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.479

High

270329

RHOJ
Rho-related GTP-binding protein RhoJ

1

15

High-throughput

0.479

High

270331

ANTR1
Anthrax toxin receptor 1

1

2

Small-scale

0.479

High

270338

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

270339

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

270351

TRAF6
TNF receptor-associated factor 6

1

4

Small-scale

0.479

High

270273

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

270292

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

0

Small-scale

0.458

High

270304

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

270320

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

0

Small-scale

0.458

High

270354

EPN1
Epsin-1

1

0

Small-scale

0.458

High

270281

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

Small-scale

0.437

High

270305

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

270309

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

270300

PAPD7
Terminal nucleotidyltransferase 4A

2

0

High-throughput

0.319

High

270297

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

270301

WDR25
WD repeat-containing protein 25

1

0

High-throughput

0.279

Low

270352

AMMR1
Nuclear protein AMMECR1

1

0

Small-scale

0.279

Low

270270

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024