Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA
Interactor 2: TPX2 (Q9ULW0)
Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)
Gene: TPX2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.983 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26831064, 14600264, 22110403, 26186194, 28514442, 12177045, 33961781, 32989298, 36736316, 18773538, 20360068, 19357306, 14580337 |
| Identification Methods | affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, x-ray crystallography, tandem affinity purification |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Aurora-A_bind~Pkinase |
| Common GO terms | GO:0000278 - mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005819 - spindle GO:0005829 - cytosol and 6 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Last updated: 15 Jul 2024
