Protein: ZW10
Centromere/kinetochore protein zw10 homolog

Gene: ZW10
Organism: Homo sapiens
Interactions: 215
UniProt ID: O43264

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000132 - establishment of mitotic spindle orientation
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211858

ZWILC
Protein zwilch homolog

2

0

Small-scale

0.770

High

211801

RINT1
RAD50-interacting protein 1

7

1

Small-scale

0.752

High

60267

NBAS
NBAS subunit of NRZ tethering complex

6

1

Small-scale

0.727

High

211872

STX18
Syntaxin-18

8

0

Small-scale

0.716

High

211757

KNTC1
Kinetochore-associated protein 1

4

3

Small-scale

0.694

High

211870

USE1
Vesicle transport protein USE1

4

0

Small-scale

0.667

High

211742

BASI
Basigin

3

1

High-throughput

0.667

High

211699

SC22B
Vesicle-trafficking protein SEC22b

3

0

High-throughput

0.646

High

211739

OPRM
Mu-type opioid receptor

2

2

High-throughput

0.628

High

211741

COPB2
Coatomer subunit beta'

2

1

Small-scale

0.618

High

211767

SNAA
Alpha-soluble NSF attachment protein

2

0

High-throughput

0.602

High

211781

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.602

High

50445

HACL2
2-hydroxyacyl-CoA lyase 2

2

0

High-throughput

0.576

High

211704

VAMP5
Vesicle-associated membrane protein 5

2

1

High-throughput

0.574

High

211827

SCFD2
Sec1 family domain-containing protein 2

2

1

High-throughput

0.574

High

211822

DHB11
Estradiol 17-beta-dehydrogenase 11

2

2

High-throughput

0.571

High

211706

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

2

0

Small-scale

0.563

High

211768

PAR2
Proteinase-activated receptor 2

2

5

High-throughput

0.558

High

211784

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

5

High-throughput

0.549

High

211887

NPTN
Neuroplastin

2

1

High-throughput

0.549

High

211777

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.547

High

211817

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

Small-scale

0.537

High

160850

STX16
Syntaxin-16

1

2

High-throughput

0.536

High

182418

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.536

High

211729

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.536

High

211765

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

211778

ACK1
Activated CDC42 kinase 1

1

2

High-throughput

0.536

High

211786

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

211842

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.536

High

211852

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.536

High

211694

SCN2B
Sodium channel regulatory subunit beta-2

2

1

High-throughput

0.521

High

129922

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

133403

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

158055

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

179758

BET1
BET1 homolog

1

0

High-throughput

0.513

High

208926

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.513

High

211693

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

211707

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.513

High

211723

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

211732

STOM
Stomatin

1

0

High-throughput

0.513

High

211747

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

211755

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

211766

MK10
Mitogen-activated protein kinase 10

1

0

High-throughput

0.513

High

211770

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.513

High

211776

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.513

High

211810

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

211818

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

211821

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.513

High

211828

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.513

High

211834

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

211841

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.513

High

211851

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

211866

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

211873

UVRAG
UV radiation resistance-associated gene protein

1

0

Small-scale

0.513

High

211878

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

211883

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

211717

INSR
Insulin receptor

1

2

High-throughput

0.500

High

211720

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

1

High-throughput

0.500

High

211743

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

211880

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

133219

P2Y10
Putative P2Y purinoceptor 10

1

5

High-throughput

0.489

High

211709

S1PR4
Sphingosine 1-phosphate receptor 4

1

2

High-throughput

0.489

High

211740

APJ
Apelin receptor

1

4

High-throughput

0.489

High

211762

EFNA4
Ephrin-A4

1

1

High-throughput

0.489

High

211763

EFNA5
Ephrin-A5

1

1

High-throughput

0.489

High

211835

ULK4
Serine/threonine-protein kinase ULK4

1

1

High-throughput

0.489

High

163860

NDC80
Kinetochore protein NDC80 homolog

1

1

Small-scale

0.484

High

211716

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

211711

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

211725

RAC2
Ras-related C3 botulinum toxin substrate 2

1

1

High-throughput

0.479

High

211727

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

211758

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

211759

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

211771

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

211780

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

211783

STX3
Syntaxin-3

1

2

High-throughput

0.479

High

211796

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.479

High

211807

PTF1A
Pancreas transcription factor 1 subunit alpha

1

0

Small-scale

0.460

High

173781

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

211696

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.458

High

211698

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

211701

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

211715

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

211726

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

211728

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

211733

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

211736

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

211745

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

211746

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

211750

PAXI
Paxillin

1

0

High-throughput

0.458

High

211751

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

211756

EMD
Emerin

1

0

High-throughput

0.458

High

211769

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

211779

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

211785

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

211794

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

211797

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

211799

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

211804

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

211808

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

211814

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

211830

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

211833

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

211837

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

211840

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

211847

DERL1
Derlin-1

1

0

High-throughput

0.458

High

211855

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

211857

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

211859

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.458

High

211868

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

211877

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

211884

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.458

High

48448

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

104304

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

171363

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

211695

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

211705

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

211708

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

211734

CALR
Calreticulin

1

1

High-throughput

0.445

High

211735

CALX
Calnexin

1

1

High-throughput

0.445

High

211754

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

211792

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

211793

DHC24
Delta(24)-sterol reductase

1

1

High-throughput

0.445

High

211798

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

211802

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.445

High

211811

UN93A
Protein unc-93 homolog A

1

1

High-throughput

0.445

High

211815

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

211825

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

211829

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

211838

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

211845

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.445

High

211850

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.445

High

211854

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

211861

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

211871

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.445

High

211874

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

211881

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

211882

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

211888

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

211714

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

211856

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

211691

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

211692

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

211700

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

211702

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.426

High

211703

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.426

High

211710

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

211712

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

211718

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

211721

TAU
Microtubule-associated protein tau

1

0

Small-scale

0.426

High

211722

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

211724

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

211731

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.426

High

211748

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

211749

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

211752

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

211760

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

211761

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

211764

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

211772

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

211773

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

211774

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

211775

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

211782

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

211787

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

211788

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

211789

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

211790

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

211791

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

211795

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

211800

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

211803

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

211806

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.426

High

211819

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

211820

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

211823

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

211824

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.426

High

211826

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

211831

S35B4
Nucleotide sugar transporter SLC35B4

1

0

High-throughput

0.426

High

211832

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

211836

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

211839

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

211844

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.426

High

211846

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

211848

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

211849

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

211853

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

211860

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.426

High

211862

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

211864

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.426

High

211865

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.426

High

211869

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

211886

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

211753

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

211730

ACKR3
Atypical chemokine receptor 3

1

4

High-throughput

0.407

High

211744

VIPR2
Vasoactive intestinal polypeptide receptor 2

3

0

High-throughput

0.345

High

211697

VAMP4
Vesicle-associated membrane protein 4

2

0

High-throughput

0.328

High

211719

ACM4
Muscarinic acetylcholine receptor M4

2

0

High-throughput

0.328

High

211876

CS025
UPF0449 protein C19orf25

2

0

Small-scale

0.328

High

211879

FZD10
Frizzled-10

2

0

High-throughput

0.328

High

211713

FINC
Fibronectin

1

0

High-throughput

0.279

Low

211737

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.279

Low

211812

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

211875

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

211885

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.269

Low

211738

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

211805

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

211809

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

211816

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

211863

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

849

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

166220

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

211813

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

211843

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

211867

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025