Protein: SPTC1
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)

Gene: SPTC1, SPTLC1
Organism: Homo sapiens
Interactions: 165
UniProt ID: O15269

Gene Ontology (top 5):
GO:0004758 - serine C-palmitoyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006665 - sphingolipid metabolic process
GO:0006686 - sphingomyelin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

174020

SPTC2
Serine palmitoyltransferase 2

2

10

Small-scale

0.783

High

174108

ORML3
ORM1-like protein 3

2

8

Small-scale

0.776

High

174090

ORML2
ORM1-like protein 2

1

8

High-throughput

0.691

High

174163

ORML1
ORM1-like protein 1

1

8

High-throughput

0.691

High

174157

SPTC3
Serine palmitoyltransferase 3

1

10

Small-scale

0.680

High

174032

EGFR
Epidermal growth factor receptor

3

2

High-throughput

0.640

High

174044

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.611

High

174029

ABCA1
Phospholipid-transporting ATPase ABCA1

2

1

Small-scale

0.594

High

174114

SPTSB
Serine palmitoyltransferase small subunit B

1

5

Small-scale

0.590

High

174124

SPTSA
Serine palmitoyltransferase small subunit A

1

5

Small-scale

0.590

High

174023

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

174093

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

123427

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

170750

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

174028

SC31A
Protein transport protein Sec31A

1

1

High-throughput

0.536

High

174039

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.536

High

174049

CALX
Calnexin

1

1

High-throughput

0.536

High

174050

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

174053

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

174055

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

174062

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.536

High

174066

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

174143

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.536

High

174171

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.515

High

174038

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

174043

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

174058

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

174065

COPB
Coatomer subunit beta

1

0

High-throughput

0.513

High

174118

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

174120

NICA
Nicastrin

1

0

High-throughput

0.513

High

174131

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

174147

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

174162

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

174165

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.513

High

174137

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.493

High

174034

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.489

High

174064

JAK3
Tyrosine-protein kinase JAK3

1

3

High-throughput

0.489

High

174084

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

174101

MON2
Protein MON2 homolog

1

1

High-throughput

0.489

High

174121

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.489

High

174152

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

1

High-throughput

0.489

High

174160

CDK12
Cyclin-dependent kinase 12

1

2

High-throughput

0.489

High

163667

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

174042

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

174054

BASI
Basigin

1

1

High-throughput

0.479

High

174070

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.479

High

174071

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

174073

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

174075

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

174078

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

174096

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

174110

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

174111

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

174136

DERL1
Derlin-1

1

1

High-throughput

0.479

High

174144

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

174154

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.470

High

174176

MAGD1
Melanoma-associated antigen D1

1

1

High-throughput

0.470

High

174097

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.470

High

174030

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

174041

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

174060

EMD
Emerin

1

0

High-throughput

0.458

High

174069

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

174092

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

174134

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

174139

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.458

High

174149

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

174175

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.458

High

174177

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

Small-scale

0.458

High

174036

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.457

High

174037

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.457

High

174112

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

174021

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

174027

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

174031

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.437

High

174045

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

174048

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

174052

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

174056

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

174063

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.437

High

174067

MOT1
Monocarboxylate transporter 1

1

2

High-throughput

0.437

High

174068

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

174074

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.437

High

174077

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

174079

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

174082

CUL3
Cullin-3

1

2

High-throughput

0.437

High

174089

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

174094

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

174098

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

174100

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.437

High

174103

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

174105

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

174106

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

174123

HDA10
Polyamine deacetylase HDAC10

1

2

High-throughput

0.437

High

174125

MFRN2
Mitoferrin-2

1

1

High-throughput

0.437

High

174127

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.437

High

174133

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.437

High

174141

TOLIP
Toll-interacting protein

1

1

High-throughput

0.437

High

174145

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

174146

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

174148

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

174153

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

174156

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

174161

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.437

High

174167

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

174169

UBQL2
Ubiquilin-2

1

3

High-throughput

0.437

High

174172

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

174024

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

174164

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

92750

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

99518

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

174040

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

174158

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.407

High

174178

X6RFA8
Solute carrier family 25 member 28

1

1

High-throughput

0.407

High

174047

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

174061

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.279

Low

174072

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.279

Low

174076

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.279

Low

174083

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.279

Low

174087

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.279

Low

174095

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

174116

FA76A
Protein FAM76A

1

0

High-throughput

0.279

Low

174128

ATG4C
Cysteine protease ATG4C

1

0

High-throughput

0.279

Low

174129

TCAL4
Transcription elongation factor A protein-like 4

1

0

High-throughput

0.279

Low

174130

NRBF2
Nuclear receptor-binding factor 2

1

0

High-throughput

0.279

Low

174135

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.279

Low

174142

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.279

Low

174151

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.279

Low

174166

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

174168

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

174174

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

174026

RGS20
Regulator of G-protein signaling 20

1

0

High-throughput

0.269

Low

174102

ANR23
Ankyrin repeat domain-containing protein 23

1

0

High-throughput

0.268

Low

174107

SLN12
Ribonuclease SLFN12

1

0

High-throughput

0.268

Low

174119

SOCS4
Suppressor of cytokine signaling 4

1

0

High-throughput

0.268

Low

174170

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.251

Low

174022

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

174025

ATP5L
ATP synthase subunit g, mitochondrial

1

0

High-throughput

0.249

Low

174033

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

174035

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

174046

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

174051

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

174057

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.249

Low

174059

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

174080

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

174081

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

174085

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.249

Low

174086

FSCN1
Fascin

1

0

High-throughput

0.249

Low

174088

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.249

Low

174091

PKHG4
Puratrophin-1

1

0

High-throughput

0.249

Low

174099

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

174104

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

174113

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

174115

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

174117

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

174122

FBX32
F-box only protein 32

1

0

Small-scale

0.249

Low

174126

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

174140

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

174150

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

174155

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

174159

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

174173

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.249

Low

847

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

174109

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

174132

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

174138

IFT27
Intraflagellar transport protein 27 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024