HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	26618866, 17110338, 29924966
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 1480
+	Hs
		529511 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		207880 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529740 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529129 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529967 TNPO3_HUMAN (24-901): 9.93e-89: 307: 14.37		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Dm
		1182028 XPO1_DROME (4-1071): 0: 905: 70.72		Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95