Protein: TCPE
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon)

Gene: TCPE, CCT5
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: P40413

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005832 - chaperonin-containing T-complex
GO:0006457 - protein folding
GO:0016887 - ATP hydrolysis activity
GO:0051082 - unfolded protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810822

TCPG
T-complex protein 1 subunit gamma

5

17

Small-scale

0.898

High

736107

ARP2
Actin-related protein 2

2

20

High-throughput

0.811

High

823632

2ABA
Protein phosphatase PP2A regulatory subunit B

3

20

High-throughput

0.770

High

554005

TCPA
T-complex protein 1 subunit alpha

2

19

Small-scale

0.754

High

811100

TCPZ
T-complex protein 1 subunit zeta

2

16

High-throughput

0.754

High

823630

ACT
Actin

2

20

Small-scale

0.737

High

793935

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

2

20

High-throughput

0.726

High

781877

CAF4
CCR4-associated factor 4

2

20

High-throughput

0.705

High

823669

CMR1
DNA damage-binding protein CMR1

2

20

High-throughput

0.675

High

823633

ACAC
Acetyl-CoA carboxylase

2

3

High-throughput

0.628

High

617401

GBB
Guanine nucleotide-binding protein subunit beta

1

20

High-throughput

0.618

High

637227

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.618

High

754290

DCA13
Protein SOF1

1

20

High-throughput

0.618

High

811594

PEX7
Peroxisomal targeting signal 2 receptor

1

20

High-throughput

0.618

High

823611

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.618

High

823665

PRP46
Pre-mRNA-splicing factor PRP46

1

20

High-throughput

0.618

High

810701

TCPB
T-complex protein 1 subunit beta

1

19

High-throughput

0.618

High

810955

TCPD
T-complex protein 1 subunit delta

1

19

High-throughput

0.618

High

823612

TCPH
T-complex protein 1 subunit eta

1

17

High-throughput

0.618

High

823618

TCPQ
T-complex protein 1 subunit theta

1

18

High-throughput

0.618

High

823645

PLP1
Phosducin-like protein 1

1

16

High-throughput

0.618

High

670788

SIS1
Protein SIS1

2

3

High-throughput

0.601

High

820330

VID27
Vacuolar import and degradation protein 27

2

3

High-throughput

0.558

High

486205

TBA1
Tubulin alpha-1 chain

1

20

High-throughput

0.553

High

486470

TBA3
Tubulin alpha-3 chain

1

20

High-throughput

0.553

High

792081

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.553

High

802066

ARP1
Centractin

1

20

High-throughput

0.553

High

823616

MDV1
Mitochondrial division protein 1

1

20

High-throughput

0.553

High

524143

HSP71
Heat shock protein SSA1

1

11

High-throughput

0.536

High

823649

KU80
ATP-dependent DNA helicase II subunit 2

1

5

High-throughput

0.536

High

823619

HGH1
Protein HGH1

2

3

Small-scale

0.533

High

734115

EF2
Elongation factor 2

2

7

High-throughput

0.521

High

823613

UTP10
U3 small nucleolar RNA-associated protein 10

2

3

High-throughput

0.521

High

823338

UTP18
U3 small nucleolar RNA-associated protein 18

1

3

High-throughput

0.514

High

823629

TBCB
Tubulin-specific chaperone B

1

2

Small-scale

0.508

High

394047

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.489

High

684624

CDC20
APC/C activator protein CDC20

1

20

High-throughput

0.489

High

702252

YJU2
Splicing factor YJU2

1

1

High-throughput

0.489

High

807229

SPT8
SAGA complex subunit SPT8

1

3

High-throughput

0.489

High

823627

BRE5
UBP3-associated protein BRE5

1

7

High-throughput

0.489

High

823635

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.489

High

823652

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

1

High-throughput

0.489

High

392832

HSP82
ATP-dependent molecular chaperone HSP82

1

12

High-throughput

0.479

High

579514

HSC82
ATP-dependent molecular chaperone HSC82

1

12

High-throughput

0.479

High

592292

VATB
V-type proton ATPase subunit B

1

10

High-throughput

0.479

High

679761

CDC48
Cell division control protein 48

1

9

High-throughput

0.479

High

682302

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.479

High

694145

CDC15
Cell division control protein 15

1

20

High-throughput

0.479

High

727080

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

737881

HOG1
Mitogen-activated protein kinase HOG1

1

12

High-throughput

0.479

High

823620

VATG
V-type proton ATPase subunit G

1

3

High-throughput

0.479

High

823643

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.479

High

823647

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.479

High

823660

PLP2
Phosducin-like protein 2

1

20

High-throughput

0.479

High

823661

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

823663

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.479

High

823668

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.479

High

518043

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.457

High

739880

RPD3
Histone deacetylase RPD3

1

20

Small-scale

0.457

High

481894

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

545108

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.445

High

778991

MYO3
Myosin-3

1

1

High-throughput

0.445

High

818916

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

823626

DBP6
ATP-dependent RNA helicase DBP6

1

4

High-throughput

0.445

High

823628

SYC
Cysteine--tRNA ligase

1

2

High-throughput

0.445

High

823653

SWR1
Helicase SWR1

1

1

High-throughput

0.445

High

382140

H4
Histone H4

1

1

High-throughput

0.437

High

435136

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.437

High

441946

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

558752

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

633474

PP11
Serine/threonine-protein phosphatase PP1-1

1

20

High-throughput

0.437

High

647130

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.437

High

660798

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

20

High-throughput

0.437

High

677429

KRR1
KRR1 small subunit processome component

1

4

High-throughput

0.437

High

707278

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

747892

SMY2
Protein SMY2

1

3

High-throughput

0.437

High

764090

SPT21
Protein SPT21

1

2

High-throughput

0.437

High

779251

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.437

High

794877

MAP2
Methionine aminopeptidase 2

1

6

High-throughput

0.437

High

812364

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

823609

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.437

High

823614

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

9

High-throughput

0.437

High

823624

PESC
Pescadillo homolog

1

2

High-throughput

0.437

High

823631

H3
Histone H3

1

9

High-throughput

0.437

High

823637

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

823638

ESP1
Separin

1

2

High-throughput

0.437

High

823639

TOM1
E3 ubiquitin-protein ligase TOM1

1

13

High-throughput

0.437

High

823641

BUL2
Ubiquitin ligase-binding protein BUL2

1

4

Small-scale

0.437

High

823642

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

2

High-throughput

0.437

High

823648

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.437

High

823650

YMW4
Uncharacterized protein YMR074C

1

6

High-throughput

0.437

High

823657

TFC6
Transcription factor tau 91 kDa subunit

1

3

High-throughput

0.437

High

823658

SGO1
Shugoshin

1

3

High-throughput

0.437

High

823662

WTM1
Transcriptional modulator WTM1

1

3

High-throughput

0.437

High

823634

ARG56
Protein ARG5,6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase

1

0

High-throughput

0.426

High

359252

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

4

High-throughput

0.407

High

394618

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

434587

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.407

High

605318

CAP
Adenylyl cyclase-associated protein

1

1

High-throughput

0.407

High

647780

RFA1
Replication factor A protein 1

1

6

High-throughput

0.407

High

655578

TKT1
Transketolase 1

1

3

High-throughput

0.407

High

726150

2AAA
Protein phosphatase PP2A regulatory subunit A

1

4

High-throughput

0.407

High

762975

SPT7
SAGA complex subunit SPT7

1

8

High-throughput

0.407

High

775947

LRG1
Rho-GTPase-activating protein LRG1

1

4

High-throughput

0.407

High

803572

RPN1
26S proteasome regulatory subunit RPN1

1

6

High-throughput

0.407

High

823615

FIP1
Pre-mRNA polyadenylation factor FIP1

1

1

High-throughput

0.407

High

823621

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

High-throughput

0.407

High

823622

HOS2
Probable histone deacetylase HOS2

1

20

High-throughput

0.407

High

823623

LSG1
Large subunit GTPase 1

1

1

High-throughput

0.407

High

823636

NOP3
Serine/arginine

1

2

High-throughput

0.407

High

823640

GCN5
Histone acetyltransferase GCN5

1

8

High-throughput

0.407

High

823646

UTP5
U3 small nucleolar RNA-associated protein 5

1

20

High-throughput

0.407

High

823651

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.407

High

823654

SGPL
Sphingosine-1-phosphate lyase

1

2

High-throughput

0.407

High

823655

UTP21
U3 small nucleolar RNA-associated protein 21

1

20

High-throughput

0.407

High

823659

ESA1
Histone acetyltransferase ESA1

1

3

High-throughput

0.407

High

823667

CEX1
Cytoplasmic export protein 1

1

10

High-throughput

0.407

High

823670

SET6
Potential protein lysine methyltransferase SET6

1

3

High-throughput

0.407

High

735009

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

823608

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

823610

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

823644

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

479685

F16P
Fructose-1,6-bisphosphatase

1

0

High-throughput

0.232

Low

672159

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.232

Low

724319

PUS3
tRNA pseudouridine(38/39) synthase

1

0

High-throughput

0.232

Low

813578

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.232

Low

818087

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.232

Low

823617

AP3S
AP-3 complex subunit sigma

1

0

High-throughput

0.232

Low

823625

PBP1
PAB1-binding protein 1

1

0

High-throughput

0.232

Low

823656

YTH1
mRNA 3'-end-processing protein YTH1

1

0

High-throughput

0.232

Low

823664

YD152
Putative uncharacterized protein YDL152W

1

0

High-throughput

0.232

Low

823666

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025