HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26673895, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 400
+	Hs
		162407 XPO1_HUMAN (1-1071): 0: 1022: 100.00		KAPCB_HUMAN (62-368): 2.15e-122: 359: 21.54
+	Hs
		162388 XPO1_HUMAN (1-1071): 0: 1022: 100.00		KAPCA_HUMAN (32-347): 6.67e-122: 358: 22.99
+	Xl
		1155763 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		AURAA_XENLA (1-339): 3.72e-121: 358: 22.16
+	Hs
		162687 XPO1_HUMAN (1-1071): 0: 1022: 100.00		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74
+	Hs
		162694 XPO1_HUMAN (1-1071): 0: 1022: 100.00		STK3_HUMAN (54-390): 1.33e-108: 329: 30.37
+	Hs
		162338 XPO1_HUMAN (1-1071): 0: 1022: 100.00		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Xl
		724509 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		CDK1A_XENLA (69-377): 5.59e-110: 326: 24.61
+	Hs
		153037 XPO1_HUMAN (1-1071): 0: 1022: 100.00		MP2K7_HUMAN (39-383): 1.39e-58: 198: 34.82
+	Sc
		434742 XPO1_YEAST (14-1067): 0: 848: 46.08		PBS2_YEAST (70-387): 1.32e-73: 243: 41.59
+	Sc
		420016 XPO1_YEAST (14-1067): 0: 848: 46.08		STE7_YEAST (71-388): 7.89e-63: 211: 36.47
+	Sc
		675888 XPO1_YEAST (14-1067): 0: 848: 46.08		MKK2_YEAST (50-369): 3.38e-53: 186: 36.15
+	Mm
		1141482 XPOT_MOUSE (29-1023): 6.32e-125: 407: 14.83		AKT2_MOUSE (31-365): 7.05e-124: 368: 19.83
+	Hs
		568799 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		KAPCA_HUMAN (32-347): 6.67e-122: 358: 22.99
+	Mm
		140327 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		MP2K3_MOUSE (19-388): 1.72e-100: 304: 32.48
+	Hs
		972197 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14
+	Hs
		625439 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Hs
		1023042 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74
+	Hs
		1023095 XPO6_HUMAN (20-380): 2.55e-64: 239: 16.71		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74