HitPredict - High confidence protein-protein interactions

Interactor 1: NRP1 (O14786)
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Gene: NRP1

Interactor 2: SEM3A (Q14563)
Semaphorin-3A (Semaphorin III) (Sema III)
Gene: SEMA3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	11886873, 10498602, unassigned3799
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CUB~Sema
Common GO terms	GO:0001755 - neural crest cell migration GO:0001764 - neuron migration GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0007411 - axon guidance and 14 others more... GO:0008045 - motor neuron axon guidance GO:0021612 - facial nerve structural organization GO:0021637 - trigeminal nerve structural organization GO:0021785 - branchiomotor neuron axon guidance GO:0030424 - axon GO:0048846 - axon extension involved in axon guidance GO:0060385 - axonogenesis involved in innervation GO:0061549 - sympathetic ganglion development GO:0071526 - semaphorin-plexin signaling pathway GO:0097490 - sympathetic neuron projection extension GO:0097491 - sympathetic neuron projection guidance GO:0098978 - glutamatergic synapse GO:0150020 - basal dendrite arborization GO:1901166 - neural crest cell migration involved in autonomic nervous system development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	923
Hs

1	771

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Last updated: 11Aug2025