HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36634849, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007416 - synapse assembly GO:0043025 - neuronal cell body
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 2390 Hs			1 758
+	Hs
		496865 SPTB2_HUMAN (3-2390): 0: 712: 61.09		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		582039 SPTN2_RAT (1-2390): 0: 716: 94.94		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94264 SPTN2_RAT (1-2390): 0: 716: 94.94		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		211474 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496188 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496988 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		555250 SPTN1_RAT (279-2273): 6.62e-79: 294: 19.13		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94140 SPTN1_RAT (279-2273): 6.62e-79: 294: 19.13		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		497051 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		503257 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		496176 DMD_HUMAN (275-2194): 6.97e-24: 113: 8.91		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497586 SPTN4_HUMAN (1248-2382): 2.34e-15: 85.3: 16.21		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		503287 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Dm
		54271 A1Z9I8_DROME (568-2369): 6.75e-11: 70.6: 9.00		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96