Protein: IMB3
Importin subunit beta-3 (Karyopherin subunit beta-3) (Karyopherin-121) (Protein secretion enhancer 1)

Gene: IMB3, PSE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 183
UniProt ID: P32337

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006406 - mRNA export from nucleus
GO:0006606 - protein import into nucleus
GO:0007088 - regulation of mitotic nuclear division

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

734638

GSP1
GTP-binding nuclear protein GSP1/CNR1

9

18

Small-scale

0.971

High

734733

IMB1
Importin subunit beta-1

4

13

Small-scale

0.892

High

734711

H3
Histone H3

3

13

Small-scale

0.870

High

419382

H2A1
Histone H2A.1

3

7

Small-scale

0.840

High

734720

IMA1
Importin subunit alpha

2

20

High-throughput

0.802

High

734639

GSP2
GTP-binding nuclear protein GSP2/CNR2

2

18

Small-scale

0.775

High

381010

H2B1
Histone H2B.1

2

4

Small-scale

0.768

High

734724

NUP53
Nucleoporin NUP53

9

4

Small-scale

0.754

High

734718

ULP1
Ubiquitin-like-specific protease 1

7

6

Small-scale

0.751

High

734746

YRA1
RNA annealing protein YRA1

5

4

Small-scale

0.720

High

381940

H4
Histone H4

5

5

Small-scale

0.716

High

734725

ARX1
Probable metalloprotease ARX1

5

1

Small-scale

0.706

High

734716

NU100
Nucleoporin NUP100/NSP100

5

20

Small-scale

0.704

High

634211

NUP1
Nucleoporin NUP1

4

20

Small-scale

0.694

High

734697

NUP57
Nucleoporin NUP57

4

20

Small-scale

0.685

High

734717

NU116
Nucleoporin NUP116/NSP116

4

20

Small-scale

0.680

High

734705

SLX9
Ribosome biogenesis protein SLX9

4

0

High-throughput

0.664

High

577274

NSP1
Nucleoporin NSP1

3

20

Small-scale

0.656

High

734699

NU145
Nucleoporin NUP145

3

20

Small-scale

0.651

High

454423

PHO4
Phosphate system positive regulatory protein PHO4

3

0

Small-scale

0.650

High

734672

ECM1
Shuttling pre-60S factor ECM1

3

1

Small-scale

0.643

High

734751

RRP12
Ribosomal RNA-processing protein 12

3

0

Small-scale

0.634

High

626480

AP1
AP-1-like transcription factor YAP1

2

2

Small-scale

0.629

High

568918

INO4
Protein INO4

3

0

High-throughput

0.629

High

526150

HSP72
Heat shock protein SSA2

3

12

Small-scale

0.624

High

636639

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.621

High

734642

PRS6A
26S proteasome regulatory subunit 6A

2

3

High-throughput

0.621

High

602117

SPO12
Sporulation-specific protein 12

2

0

Small-scale

0.618

High

734654

CENPA
Histone H3-like centromeric protein CSE4

1

13

High-throughput

0.618

High

734695

ALB1
Ribosome biogenesis protein ALB1

2

0

Small-scale

0.616

High

734703

DUO1
DASH complex subunit DUO1

3

0

Small-scale

0.616

High

734713

CDC14
Tyrosine-protein phosphatase CDC14

2

15

Small-scale

0.611

High

734667

AURK
Aurora kinase

2

3

Small-scale

0.611

High

734735

DBP9
ATP-dependent RNA helicase DBP9

3

4

High-throughput

0.609

High

513341

RL23B
Large ribosomal subunit protein uL14B

2

1

Small-scale

0.602

High

734708

PAP2
Poly(A) RNA polymerase protein 2

2

1

High-throughput

0.601

High

661475

PSA2
Proteasome subunit alpha type-2

2

0

High-throughput

0.595

High

734680

PSA6
Proteasome subunit alpha type-6

2

0

High-throughput

0.595

High

734681

PSA4
Proteasome subunit alpha type-4

2

0

High-throughput

0.595

High

734702

MDS3
Negative regulator of sporulation MDS3

2

0

High-throughput

0.595

High

734730

YM91
Putative methyltransferase YMR310C

2

0

High-throughput

0.595

High

561433

TBP
TATA-box-binding protein

2

1

Small-scale

0.595

High

734715

NUP49
Nucleoporin NUP49/NSP49

2

20

Small-scale

0.595

High

564646

STE12
Protein STE12

2

0

Small-scale

0.592

High

636552

PSA7
Probable proteasome subunit alpha type-7

2

1

High-throughput

0.588

High

734643

PRS6B
26S proteasome regulatory subunit 6B homolog

2

3

High-throughput

0.588

High

734671

BDH2
Probable diacetyl reductase [(R)-acetoin forming] 2

2

3

High-throughput

0.588

High

734649

NIC96
Nucleoporin NIC96

1

3

Small-scale

0.578

High

734706

DAM1
DASH complex subunit DAM1

2

0

Small-scale

0.576

High

434917

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.571

High

575407

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

2

2

High-throughput

0.567

High

594906

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

2

1

High-throughput

0.567

High

654707

SPA2
Protein SPA2

2

3

High-throughput

0.567

High

734634

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

2

1

High-throughput

0.567

High

544127

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.552

High

734656

YRA2
RNA annealing protein YRA2

1

0

Small-scale

0.537

High

734685

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

6

High-throughput

0.537

High

448149

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.536

High

453474

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.536

High

486080

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.536

High

636456

ACE2
Metallothionein expression activator

1

1

High-throughput

0.515

High

689752

FEN1
Flap endonuclease 1

1

1

High-throughput

0.515

High

734678

GLE2
mRNA export factor GLE2

1

5

High-throughput

0.515

High

734647

DCA13
Protein SOF1

1

5

Small-scale

0.512

High

734673

RV167
Reduced viability upon starvation protein 167

1

2

Small-scale

0.508

High

734700

GCH1
GTP cyclohydrolase 1

1

1

High-throughput

0.508

High

488365

HO
Homothallic switching endonuclease

1

0

Small-scale

0.504

High

734636

NUP2
Nucleoporin NUP2

1

20

Small-scale

0.501

High

734658

NU133
Nucleoporin NUP133

1

1

Small-scale

0.501

High

734670

NUP60
Nucleoporin NUP60

1

2

Small-scale

0.501

High

734689

T2FB
Transcription initiation factor IIF subunit beta

1

1

Small-scale

0.501

High

734701

NU188
Nucleoporin NUP188

1

1

Small-scale

0.501

High

734737

TSR2
Pre-rRNA-processing protein TSR2

1

2

Small-scale

0.501

High

734738

ASR1
Alcohol-sensitive RING finger protein 1

1

3

Small-scale

0.501

High

734743

RKM1
Ribosomal lysine N-methyltransferase 1

1

2

Small-scale

0.501

High

734745

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

2

Small-scale

0.501

High

692489

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.493

High

734677

THO1
Protein THO1

1

0

High-throughput

0.493

High

734707

NOP19
Nucleolar protein 19

1

0

High-throughput

0.493

High

734750

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.493

High

734655

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.489

High

734665

AIM46
Altered inheritance of mitochondria protein 46, mitochondrial

1

1

High-throughput

0.489

High

624457

RDS2
Regulator of drug sensitivity 2

1

0

High-throughput

0.486

High

684903

DAL80
Nitrogen regulatory protein DAL80

1

0

High-throughput

0.486

High

734664

DNPEP
Aspartyl aminopeptidase 4

1

0

High-throughput

0.486

High

734676

ACA1
ATF/CREB activator 1

1

0

High-throughput

0.486

High

734686

MND2
Anaphase-promoting complex subunit MND2

1

0

High-throughput

0.486

High

734729

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.486

High

734741

RDR1
Protein RDR1

1

0

High-throughput

0.486

High

734749

WTM2
Transcriptional modulator WTM2

1

0

High-throughput

0.486

High

570792

ABF1
ARS-binding factor 1

1

0

Small-scale

0.480

High

645596

AFT1
Iron-regulated transcriptional activator AFT1

1

0

Small-scale

0.480

High

734736

BCP1
Protein BCP1

1

0

Small-scale

0.480

High

149645

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

392396

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.479

High

435842

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

579023

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.479

High

647038

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

649580

KCC2
Calcium/calmodulin-dependent protein kinase II

1

4

High-throughput

0.479

High

670448

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

674478

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

706463

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

734633

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

734641

SMY2
Protein SMY2

1

3

High-throughput

0.479

High

734651

DEF1
RNA polymerase II degradation factor 1

1

2

High-throughput

0.479

High

734652

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

734661

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.479

High

734662

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

734679

IMB4
Importin subunit beta-4

1

12

High-throughput

0.479

High

734684

NU159
Nucleoporin NUP159

1

20

Small-scale

0.479

High

734687

SAS2
Histone acetyltransferase SAS2

1

3

Small-scale

0.479

High

734692

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

734696

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

734704

CDH1
APC/C activator protein CDH1

1

12

Small-scale

0.479

High

734709

HST2
NAD-dependent protein deacetylase HST2

1

7

High-throughput

0.479

High

734710

UFD2
E4 ubiquitin-protein ligase UFD2

1

1

High-throughput

0.479

High

734714

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

734727

SXM1
Importin beta SMX1

1

12

High-throughput

0.479

High

734748

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

734752

SAS5
Something about silencing protein 5

1

1

Small-scale

0.479

High

368146

THDH
Threonine dehydratase, mitochondrial

1

2

High-throughput

0.464

High

619336

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.464

High

734650

DHSO1
Sorbitol dehydrogenase 1

1

3

High-throughput

0.464

High

734653

AP1B1
AP-1 complex subunit beta-1

1

1

High-throughput

0.464

High

734739

DHSO2
Sorbitol dehydrogenase 2

1

3

High-throughput

0.464

High

448291

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

553517

PDR1
Transcription factor PDR1

1

0

Small-scale

0.458

High

585476

KCY
Uridylate kinase

1

0

High-throughput

0.458

High

734683

NUP82
Nucleoporin NUP82

1

0

Small-scale

0.458

High

734691

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

Small-scale

0.458

High

734728

PUF6
Pumilio homology domain family member 6

1

0

Small-scale

0.458

High

734734

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

734668

RS14B
Small ribosomal subunit protein uS11B

1

5

Small-scale

0.457

High

734674

RS26A
Small ribosomal subunit protein eS26A

1

4

Small-scale

0.457

High

734675

RS26B
Small ribosomal subunit protein eS26B

1

4

Small-scale

0.457

High

734698

NUP42
Nucleoporin NUP42

1

20

Small-scale

0.457

High

734732

NUP59
Nucleoporin ASM4

1

4

Small-scale

0.457

High

734747

POM33
Pore membrane protein of 33 kDa

1

4

Small-scale

0.457

High

386618

TBB
Tubulin beta chain

1

3

High-throughput

0.445

High

394338

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

432517

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.445

High

523326

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

531652

RL4A
Large ribosomal subunit protein uL4A

1

5

High-throughput

0.445

High

592084

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.445

High

734637

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

734644

PRS7
26S proteasome regulatory subunit 7 homolog

1

9

High-throughput

0.445

High

734646

MSN2
Zinc finger protein MSN2

1

2

High-throughput

0.445

High

734688

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.445

High

734690

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.445

High

734694

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

734726

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.445

High

383581

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

409995

RL25
Large ribosomal subunit protein uL23

1

3

Small-scale

0.437

High

502912

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

585229

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.437

High

682199

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

734632

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

6

High-throughput

0.437

High

734635

ERG1
Squalene epoxidase ERG1

1

3

High-throughput

0.437

High

734640

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

734645

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

6

High-throughput

0.437

High

734648

GCN1
eIF-2-alpha kinase activator GCN1

1

11

High-throughput

0.437

High

734659

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.437

High

734660

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.437

High

734669

ELO1
Fatty acid elongase 1

1

4

High-throughput

0.437

High

734682

ELO3
Fatty acid elongase 3

1

4

High-throughput

0.437

High

734712

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

734722

YM59
Uncharacterized protein YMR209C

1

1

High-throughput

0.437

High

734740

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

734742

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

364974

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

734719

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.426

High

613844

ERD2
ER lumen protein-retaining receptor

1

3

High-throughput

0.407

High

734663

LAG1
Ceramide synthase LAG1

1

5

High-throughput

0.407

High

734590

NUD1
Protein NUD1

2

0

High-throughput

0.307

High

734731

NTE1
Lysophospholipase NTE1

2

0

High-throughput

0.307

High

734666

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.265

Low

734721

AAD16
Putative aryl-alcohol dehydrogenase AAD16

1

0

High-throughput

0.265

Low

734744

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.261

Low

511389

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.249

Low

689326

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

734657

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

734693

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.249

Low

734723

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025