HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31501420, 38280479
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030054 - cell junction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2390 Hs			1 504
+	Hs
		963426 SPTB2_HUMAN (3-2390): 0: 712: 61.09		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		808520 SPTB2_HUMAN (3-2390): 0: 712: 61.09		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		521619 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		521493 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		1045530 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		808589 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		211645 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32
+	Hs
		808624 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		1045510 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		521598 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32
+	Dm
		1182589 Q7KV70_DROME (452-2383): 2.29e-53: 210: 15.05		KIBRA_DROME (169-320): 3.18e-32: 133: 28.29