Protein: MICA
MHC class I polypeptide-related sequence A (MIC-A)

Gene: MICA
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q29983

Gene Ontology (top 5):
GO:0001913 - T cell mediated cytotoxicity
GO:0002418 - immune response to tumor cell
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163308

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

1

High-throughput

0.861

High

1144601

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

7

High-throughput

0.861

High

1147334

EPHA7
Ephrin type-A receptor 7

2

7

High-throughput

0.811

High

688699

NKG2D
NKG2-D type II integral membrane protein

2

20

Small-scale

0.778

High

1177144

MICB
MHC class I polypeptide-related sequence B

2

16

High-throughput

0.776

High

437688

HEPS
Serine protease hepsin

1

14

High-throughput

0.691

High

567777

TF
Tissue factor

1

1

High-throughput

0.691

High

732983

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.691

High

1160909

PRSS8
Prostasin

1

12

High-throughput

0.691

High

1177251

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

5

High-throughput

0.691

High

178788

SCAM1
Secretory carrier-associated membrane protein 1

3

1

High-throughput

0.667

High

761233

RYK
Tyrosine-protein kinase RYK

3

18

High-throughput

0.667

High

834664

TNFL9
Tumor necrosis factor ligand superfamily member 9

3

3

High-throughput

0.667

High

1154627

VAMP3
Vesicle-associated membrane protein 3

3

2

High-throughput

0.667

High

1177256

TNPO3
Transportin-3

3

4

High-throughput

0.667

High

1177258

FLVC1
Choline/ethanolamine transporter FLVCR1

3

1

High-throughput

0.667

High

1177236

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.656

High

164579

TNPO2
Transportin-2

3

1

High-throughput

0.656

High

1177245

PHF7
E3 ubiquitin-protein ligase PHF7

3

0

High-throughput

0.638

High

1177247

ADAP2
Arf-GAP with dual PH domain-containing protein 2

3

0

High-throughput

0.638

High

1030784

DEF5
Defensin alpha 5

2

1

High-throughput

0.628

High

1177217

TECT1
Tectonic-1

2

5

High-throughput

0.628

High

363355

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

410879

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

774390

BASI
Basigin

1

6

High-throughput

0.618

High

787175

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

High-throughput

0.618

High

1177222

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

20

High-throughput

0.618

High

1160383

TAZ
Tafazzin

3

2

High-throughput

0.609

High

351684

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.602

High

1177225

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.602

High

1177240

ESPB1
Epididymal sperm-binding protein 1

2

2

High-throughput

0.601

High

1177239

GGH
Gamma-glutamyl hydrolase

2

0

High-throughput

0.585

High

1177242

PGRP3
Peptidoglycan recognition protein 3

2

0

High-throughput

0.585

High

1177235

TM87A
Transmembrane protein 87A

2

0

High-throughput

0.576

High

1177253

CLC4A
C-type lectin domain family 4 member A

1

19

High-throughput

0.575

High

181330

PGRC2
Membrane-associated progesterone receptor component 2

1

3

High-throughput

0.553

High

290322

KS6A4
Ribosomal protein S6 kinase alpha-4

1

1

High-throughput

0.536

High

328674

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.536

High

351898

S1PR4
Sphingosine 1-phosphate receptor 4

1

3

High-throughput

0.536

High

719929

HMOX2
Heme oxygenase 2

1

2

High-throughput

0.536

High

749336

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

1

High-throughput

0.536

High

839286

MTOR
Serine/threonine-protein kinase mTOR

1

7

High-throughput

0.536

High

902196

RAB13
Ras-related protein Rab-13

1

2

High-throughput

0.536

High

947991

DEF1
Neutrophil defensin 1

1

1

High-throughput

0.536

High

1010039

DLK1
Protein delta homolog 1

1

2

High-throughput

0.536

High

1062168

PCDH1
Protocadherin-1

1

9

High-throughput

0.536

High

1128897

I13R2
Interleukin-13 receptor subunit alpha-2

1

9

High-throughput

0.536

High

1144925

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.536

High

1159199

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.536

High

1177224

I27RA
Interleukin-27 receptor subunit alpha

1

8

High-throughput

0.536

High

1177227

SE6L2
Seizure 6-like protein 2

1

1

High-throughput

0.536

High

1177228

TAFA3
Chemokine-like protein TAFA-3

1

1

High-throughput

0.536

High

1177230

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

2

High-throughput

0.536

High

1177232

S39AB
Zinc transporter ZIP11

1

17

High-throughput

0.536

High

1177234

TAFA2
Chemokine-like protein TAFA-2

1

1

High-throughput

0.536

High

1177246

AP1M1
AP-1 complex subunit mu-1

1

2

High-throughput

0.536

High

1177254

ITM2B
Integral membrane protein 2B

1

6

High-throughput

0.536

High

609694

LEG3
Galectin-3

1

1

Small-scale

0.515

High

377034

NEU2
Vasopressin-neurophysin 2-copeptin

1

0

High-throughput

0.513

High

378627

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

933179

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

1041664

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.513

High

1154041

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.513

High

1177218

DB136
Defensin beta 136

1

0

High-throughput

0.513

High

1177226

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.513

High

1177231

D107A
Beta-defensin 107

1

0

High-throughput

0.513

High

1177237

LCN9
Epididymal-specific lipocalin-9

1

0

High-throughput

0.513

High

1177243

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.513

High

1177244

RETNB
Resistin-like beta

1

0

High-throughput

0.513

High

1177250

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.513

High

1162941

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.493

High

1177229

WFDC3
WAP four-disulfide core domain protein 3

1

0

High-throughput

0.493

High

165588

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.489

High

231488

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.489

High

880016

DNSL1
Deoxyribonuclease-1-like 1

1

4

High-throughput

0.489

High

218242

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

376506

LDLR
Low-density lipoprotein receptor

1

4

High-throughput

0.479

High

1140352

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1177248

T106B
Transmembrane protein 106B

1

6

High-throughput

0.479

High

1177252

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

222278

PSCA
Prostate stem cell antigen

1

2

High-throughput

0.445

High

1177221

Q4LE60
TNPO2 variant protein

1

1

High-throughput

0.445

High

1177233

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.445

High

1065933

VAC14
Protein VAC14 homolog

1

4

High-throughput

0.437

High

1177220

DB109
Beta-defensin 109B

1

0

High-throughput

0.426

High

342572

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.407

High

1177238

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.407

High

1177241

ERLEC
Endoplasmic reticulum lectin 1

3

0

High-throughput

0.347

High

1177255

AAR2
Protein AAR2 homolog

2

0

High-throughput

0.318

High

1177249

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

252214

ISK4
Serine protease inhibitor Kazal-type 4

1

0

High-throughput

0.279

Low

505899

S31D3
Spermatogenesis-associated protein 31D3

1

0

High-throughput

0.279

Low

942376

EP3B
Epididymal secretory protein E3-beta

1

0

High-throughput

0.279

Low

1085226

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.279

Low

1103093

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1177219

DB135
Beta-defensin 135

1

0

High-throughput

0.279

Low

1177223

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1177257

INSL5
Insulin-like peptide INSL5

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025