HitPredict

Interactor 1: SET1A (O15047)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
Gene: SETD1A

Interactor 2: DPY30 (Q9C005)
Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)
Gene: DPY30

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	23453808, 23870121, 31076518, 24981860, 17500065
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1707 Hs			1 99
+	Hs
		1318622 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		975318 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1318624 SET1B_HUMAN (257-1707): 2.03e-55: 216: 23.18		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Sp
		252202 SET1_SCHPO (1173-1707): 7.33e-76: 275: 27.60		SDC1_SCHPO (48-89): 9.88e-13: 60.5: 47.62
+	Dm
		1129081 SET1_DROME (18-215): 6.29e-54: 210: 34.67		DPY30_DROME (42-99): 1.39e-24: 91.7: 51.72
+	Hs
		152687 KMT2D_HUMAN (1567-1707): 6.69e-18: 93.2: 46.15		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1243840 KMT2C_HUMAN (373-1440): 5.88e-09: 63.6: 10.72		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00