HitPredict

Interactor 1: PER2 (O15055)
Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
Gene: PER2

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35122331
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 732
+	Hs
		432199 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		165921 PER2_HUMAN (1-1255): 0: 569: 100.00		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		431903 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		126097 BMAL1_HUMAN (20-577): 1.21e-107: 354: 16.83		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Mm
		432431 HIF1A_MOUSE (83-819): 7.28e-106: 356: 12.26		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Hs
		431737 SIM1_HUMAN (96-768): 1.46e-99: 336: 13.43		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438217 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Mm
		432429 SIM1_MOUSE (96-786): 1.8e-96: 328: 11.31		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Hs
		431556 ARNT_HUMAN (9-727): 5.1e-92: 316: 14.98		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431844 SIM2_HUMAN (96-763): 7.37e-89: 304: 13.26		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432201 EPAS1_HUMAN (82-890): 3.42e-86: 302: 11.26		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431594 AHR_HUMAN (70-897): 2.09e-85: 299: 10.16		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438165 SIM2_HUMAN (96-763): 7.37e-89: 304: 13.26		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Mm
		432410 AHR_MOUSE (75-891): 1.5e-77: 276: 9.70		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Rn
		783943 AHR_RAT (75-941): 1.8e-76: 273: 10.28		HS90A_RAT (1-732): 0: 1085: 97.95
+	Mm
		513659 AHR_MOUSE (75-891): 1.5e-77: 276: 9.70		HS90B_MOUSE (19-732): 0: 1063: 86.98
+	Dm
		1096504 SIMA_DROME (82-831): 4.55e-72: 267: 11.06		Q9VAY2_DROME (15-700): 0: 537: 46.13