Protein: VKGC
Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)

Gene: VKGC, GGCX
Organism: Homo sapiens
Interactions: 70
UniProt ID: P38435

Gene Ontology (top 5):
GO:0005788 - endoplasmic reticulum lumen
GO:0005789 - endoplasmic reticulum membrane
GO:0007596 - blood coagulation
GO:0008488 - gamma-glutamyl carboxylase activity
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800216

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.602

High

395617

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

800236

FBX6
F-box only protein 6

2

1

High-throughput

0.558

High

160925

TMG1
Transmembrane gamma-carboxyglutamic acid protein 1

1

2

High-throughput

0.536

High

182483

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

800231

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

2

High-throughput

0.536

High

800244

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

49732

TMM72
Transmembrane protein 72

1

0

High-throughput

0.513

High

575640

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.513

High

635420

C4BPB
C4b-binding protein beta chain

1

0

High-throughput

0.513

High

698446

CALX
Calnexin

1

0

High-throughput

0.513

High

800213

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

800221

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

800224

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

800226

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

800233

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

800235

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

0

High-throughput

0.513

High

800243

CLC2D
C-type lectin domain family 2 member D

1

0

High-throughput

0.513

High

165913

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

709258

AA2BR
Adenosine receptor A2b

1

1

High-throughput

0.489

High

771097

APJ
Apelin receptor

1

1

High-throughput

0.489

High

800205

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

800246

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

173875

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

217909

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

377437

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

766256

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

800210

CUL3
Cullin-3

1

0

High-throughput

0.458

High

800215

GRDN
Girdin

1

0

High-throughput

0.458

High

800229

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

800230

DERL1
Derlin-1

1

0

High-throughput

0.458

High

653713

PROZ
Vitamin K-dependent protein Z

1

1

High-throughput

0.445

High

800225

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

379915

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

800211

S39AE
Metal cation symporter ZIP14

1

0

High-throughput

0.426

High

800222

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

139184

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

219281

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

260841

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

482233

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

749178

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

800204

AP1S2
AP-1 complex subunit sigma-2

1

0

High-throughput

0.279

Low

800208

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

0

High-throughput

0.279

Low

800219

S22A9
Organic anion transporter 7

1

0

High-throughput

0.279

Low

800220

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

800223

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.279

Low

800227

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

800234

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.279

Low

800238

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.279

Low

800240

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

800241

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

172034

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

0

High-throughput

0.269

Low

800212

SAFB1
Scaffold attachment factor B1

1

0

High-throughput

0.269

Low

800207

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.261

Low

293313

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

400407

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

694792

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

800203

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

800206

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

800209

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

800214

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

800217

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

800218

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.249

Low

800228

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

800232

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

800237

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

800239

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

800242

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

800245

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

653171

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025