HitPredict

Interactor 1: PER2 (O15055)
Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
Gene: PER2

Interactor 2: BHE41 (Q9C0J9)
Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1)
Gene: BHLHE41

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	23555304
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0032922 - circadian regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription GO:0050767 - regulation of neurogenesis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 482
+	Hs
		126088 PER2_HUMAN (1-1255): 0: 569: 100.00		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Mm
		222716 PER2_MOUSE (1-1255): 2.02e-144: 472: 76.53		BMAL1_MOUSE (32-469): 5.73e-93: 296: 15.79
+	Mm
		222710 PER2_MOUSE (1-1255): 2.02e-144: 472: 76.53		BHE41_MOUSE (1-482): 1.15e-80: 258: 66.87
+	Hs
		1085667 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		BHE41_HUMAN (1-482): 9.25e-107: 327: 100.00
+	Hs
		126165 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Hs
		126155 BMAL2_HUMAN (51-596): 2.02e-117: 381: 19.67		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Hs
		126132 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Dm
		247692 PER_DROME (191-1159): 2.63e-139: 457: 16.94		CYCL_DROME (37-421): 5.18e-60: 204: 15.48
+	Hs
		87730 D0VY79_HUMAN (83-782): 1.15e-108: 363: 11.72		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Mm
		1142409 HIF1A_MOUSE (83-819): 7.28e-106: 356: 12.26		BMAL1_MOUSE (32-469): 5.73e-93: 296: 15.79
+	Hs
		126086 BMAL1_HUMAN (20-577): 1.21e-107: 354: 16.83		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Hs
		146540 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		BHE40_HUMAN (14-445): 6.19e-72: 235: 39.50
+	Hs
		1264406 NPAS2_HUMAN (85-888): 5.99e-118: 389: 14.56		BMAL2_HUMAN (46-435): 7.87e-68: 230: 13.53
+	Mm
		250757 PER3_MOUSE (59-1233): 3.78e-87: 309: 32.02		BMAL1_MOUSE (32-469): 5.73e-93: 296: 15.79
+	Hs
		126166 EPAS1_HUMAN (82-890): 3.42e-86: 302: 11.26		BMAL1_HUMAN (32-469): 9.1e-94: 298: 15.35
+	Mm
		193665 PER1_MOUSE (9-1230): 1.65e-84: 304: 39.10		BMAL1_MOUSE (32-469): 5.73e-93: 296: 15.79
+	Hs
		182369 PER1_HUMAN (21-1234): 2.75e-86: 309: 38.90		BMAL2_HUMAN (46-435): 7.87e-68: 230: 13.53
+	Hs
		649169 ARNT_HUMAN (9-727): 5.1e-92: 316: 14.98		HEY2_HUMAN (18-331): 1.34e-49: 174: 20.38
+	Hs
		649177 ARNT_HUMAN (9-727): 5.1e-92: 316: 14.98		HEY1_HUMAN (29-318): 9.93e-50: 173: 23.47