Protein: OPRM
Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)

Gene: OPRM, OPRM1
Organism: Homo sapiens
Interactions: 140
UniProt ID: P35372

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0004930 - G protein-coupled receptor activity
GO:0004979 - beta-endorphin receptor activity
GO:0005245 - voltage-gated calcium channel activity
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

770929

LPAR3
Lysophosphatidic acid receptor 3

2

14

High-throughput

0.783

High

770827

OPRD
Delta-type opioid receptor

2

13

Small-scale

0.754

High

572418

DRD2
D(2) dopamine receptor

1

20

Small-scale

0.724

High

770828

OPRX
Nociceptin receptor

1

13

Small-scale

0.724

High

770864

WLS
Protein wntless homolog

4

6

Small-scale

0.712

High

770906

RANB9
Ran-binding protein 9

2

3

Small-scale

0.654

High

764202

CXA4
Gap junction alpha-4 protein

2

5

Small-scale

0.651

High

770927

VAPA
Vesicle-associated membrane protein-associated protein A

2

7

Small-scale

0.651

High

211739

ZW10
Centromere/kinetochore protein zw10 homolog

2

2

High-throughput

0.628

High

770831

HD
Huntingtin

2

1

High-throughput

0.628

High

770853

ATR
Serine/threonine-protein kinase ATR

2

13

High-throughput

0.628

High

770865

AB17B
Alpha/beta hydrolase domain-containing protein 17B

2

9

High-throughput

0.628

High

770866

ECM29
Proteasome adapter and scaffold protein ECM29

2

7

High-throughput

0.628

High

770868

LMBD2
G-protein coupled receptor-associated protein LMBRD2

2

9

High-throughput

0.628

High

770870

RINT1
RAD50-interacting protein 1

2

5

High-throughput

0.628

High

770893

COG1
Conserved oligomeric Golgi complex subunit 1

2

1

High-throughput

0.628

High

770903

COG3
Conserved oligomeric Golgi complex subunit 3

2

1

High-throughput

0.628

High

770904

COG8
Conserved oligomeric Golgi complex subunit 8

2

1

High-throughput

0.628

High

770905

XPO6
Exportin-6

2

3

High-throughput

0.628

High

482579

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

17

Small-scale

0.618

High

636204

MAL
Myelin and lymphocyte protein

2

3

High-throughput

0.606

High

692182

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

1

High-throughput

0.606

High

770837

EMP1
Epithelial membrane protein 1

2

3

High-throughput

0.606

High

770838

EMP3
Epithelial membrane protein 3

2

3

High-throughput

0.606

High

770839

BI1
Bax inhibitor 1

2

4

High-throughput

0.606

High

770840

CLD8
Claudin-8

2

2

High-throughput

0.606

High

770842

CLD10
Claudin-10

2

2

High-throughput

0.606

High

770845

PMP22
Peripheral myelin protein 22

2

3

High-throughput

0.606

High

770849

SMAGP
Small cell adhesion glycoprotein

2

1

High-throughput

0.606

High

770850

MALL
MAL-like protein

2

3

High-throughput

0.606

High

770884

S41A1
Solute carrier family 41 member 1

2

1

High-throughput

0.606

High

770888

LRC25
Leucine-rich repeat-containing protein 25

2

1

High-throughput

0.606

High

770891

CLD22
Claudin-22

2

2

High-throughput

0.606

High

770908

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

9

High-throughput

0.606

High

770910

CLC7A
C-type lectin domain family 7 member A

2

3

High-throughput

0.606

High

770924

S38A7
Sodium-coupled neutral amino acid transporter 7

2

1

High-throughput

0.606

High

770843

COG7
Conserved oligomeric Golgi complex subunit 7

2

0

High-throughput

0.602

High

770937

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

3

Small-scale

0.586

High

155442

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.580

High

220356

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.580

High

630125

AL5AP
Arachidonate 5-lipoxygenase-activating protein

2

0

High-throughput

0.580

High

770830

NSG1
Neuronal vesicle trafficking-associated protein 1

2

0

High-throughput

0.580

High

770846

IFM3
Interferon-induced transmembrane protein 3

2

0

High-throughput

0.580

High

770890

SERP2
Stress-associated endoplasmic reticulum protein 2

2

0

High-throughput

0.580

High

770938

TX264
Testis-expressed protein 264

2

0

High-throughput

0.580

High

137192

EXOC5
Exocyst complex component 5

2

1

High-throughput

0.574

High

187474

FANCA
Fanconi anemia group A protein

2

3

High-throughput

0.574

High

223706

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

2

2

High-throughput

0.574

High

318120

IPO13
Importin-13

2

14

High-throughput

0.574

High

360257

COX1
Cytochrome c oxidase subunit 1

2

1

High-throughput

0.574

High

770852

ATM
Serine-protein kinase ATM

2

14

High-throughput

0.574

High

770854

URB2
Unhealthy ribosome biogenesis protein 2 homolog

2

2

High-throughput

0.574

High

770855

COG2
Conserved oligomeric Golgi complex subunit 2

2

2

High-throughput

0.574

High

770861

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

9

High-throughput

0.574

High

770862

NOM1
Nucleolar MIF4G domain-containing protein 1

2

2

High-throughput

0.574

High

770869

ZFY26
Zinc finger FYVE domain-containing protein 26

2

4

High-throughput

0.574

High

770871

TTI2
TELO2-interacting protein 2

2

2

High-throughput

0.574

High

770872

MZT2B
Mitotic-spindle organizing protein 2B

2

4

High-throughput

0.574

High

770873

MBOA5
Lysophospholipid acyltransferase 5

2

7

High-throughput

0.574

High

770874

BRAT1
Integrator complex assembly factor BRAT1

2

2

High-throughput

0.574

High

770875

THADA
tRNA

2

4

High-throughput

0.574

High

770878

MON2
Protein MON2 homolog

2

7

High-throughput

0.574

High

770879

ADCK1
AarF domain-containing protein kinase 1

2

6

High-throughput

0.574

High

770880

DAAF5
Dynein axonemal assembly factor 5

2

4

High-throughput

0.574

High

770887

INT1
Integrator complex subunit 1

2

5

High-throughput

0.574

High

770889

STAG2
Cohesin subunit SA-2

2

2

High-throughput

0.574

High

770898

GCP3
Gamma-tubulin complex component 3

2

9

High-throughput

0.574

High

770909

GCP2
Gamma-tubulin complex component 2

2

9

High-throughput

0.574

High

770914

XPO4
Exportin-4

2

15

High-throughput

0.574

High

770920

ZWILC
Protein zwilch homolog

2

1

High-throughput

0.574

High

770921

COG4
Conserved oligomeric Golgi complex subunit 4

2

2

High-throughput

0.574

High

770923

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

3

High-throughput

0.574

High

770930

MTFP1
Mitochondrial fission process protein 1

2

1

High-throughput

0.574

High

770933

GCP4
Gamma-tubulin complex component 4

2

9

High-throughput

0.574

High

770934

IPO11
Importin-11

2

13

High-throughput

0.574

High

770935

XPO7
Exportin-7

2

20

High-throughput

0.574

High

770931

DNJB4
DnaJ homolog subfamily B member 4

1

1

Small-scale

0.573

High

336156

CNIH1
Protein cornichon homolog 1

2

1

High-throughput

0.553

High

770835

CLCN7
H(+)/Cl(-) exchange transporter 7

2

1

High-throughput

0.553

High

770858

CL12B
C-type lectin domain family 12 member B

2

3

High-throughput

0.553

High

770859

CTXN3
Cortexin-3

2

1

High-throughput

0.553

High

770902

SC22A
Vesicle-trafficking protein SEC22a

2

2

High-throughput

0.553

High

770911

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

4

High-throughput

0.553

High

770919

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

2

4

High-throughput

0.553

High

770922

RPRM
Protein reprimo

2

1

High-throughput

0.553

High

770829

PI4KA
Phosphatidylinositol 4-kinase alpha

2

8

High-throughput

0.552

High

770836

SC5A3
Sodium/myo-inositol cotransporter

2

3

High-throughput

0.552

High

770851

GRM1
Metabotropic glutamate receptor 1

1

6

High-throughput

0.541

High

770883

SL9A9
Sodium/hydrogen exchanger 9

1

3

High-throughput

0.541

High

770901

S39AD
Zinc transporter ZIP13

1

13

High-throughput

0.541

High

770915

YIPF3
Protein YIPF3

1

4

High-throughput

0.541

High

770917

KCNF1
Voltage-gated potassium channel regulatory subunit KCNF1

1

7

Small-scale

0.541

High

770932

ADDG
Gamma-adducin

1

3

High-throughput

0.541

High

178614

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

2

High-throughput

0.536

High

770877

DYM
Dymeclin

1

7

High-throughput

0.536

High

770894

CHPT1
Cholinephosphotransferase 1

1

4

High-throughput

0.536

High

770881

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

7

Small-scale

0.535

High

770892

DOK4
Docking protein 4

1

3

Small-scale

0.535

High

770896

CSN5
COP9 signalosome complex subunit 5

1

2

Small-scale

0.535

High

770860

Q4LE69
Phosphatidylinositol 4-kinase alpha

2

7

High-throughput

0.533

High

770918

NELFA
Negative elongation factor A

1

2

High-throughput

0.532

High

637371

FLNA
Filamin-A

1

4

Small-scale

0.529

High

770857

ZYX
Zyxin

1

0

Small-scale

0.529

High

211537

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

7

Small-scale

0.523

High

165137

CPLX1
Complexin-1

1

0

High-throughput

0.518

High

239484

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

1

0

High-throughput

0.518

High

507605

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

770899

RTP4
Receptor-transporting protein 4

1

2

High-throughput

0.494

High

226413

SNG2
Synaptogyrin-2

1

3

High-throughput

0.489

High

665532

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

4

High-throughput

0.489

High

770841

GEMI4
Gem-associated protein 4

1

1

High-throughput

0.489

High

770895

GCN1
Stalled ribosome sensor GCN1

1

10

High-throughput

0.489

High

770897

S2546
Mitochondrial outer membrane protein SLC25A46

1

2

High-throughput

0.489

High

770912

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.489

High

770936

TNPO3
Transportin-3

1

14

High-throughput

0.489

High

770886

TARG1
Trafficking regulator of GLUT4 1

1

6

High-throughput

0.481

High

168822

PLD2
Phospholipase D2

1

3

Small-scale

0.479

High

770844

ARF1
ADP-ribosylation factor 1

1

4

Small-scale

0.479

High

770907

SGMR1
Sigma non-opioid intracellular receptor 1

1

4

Small-scale

0.479

High

63641

A5PKU2
TUSC5 protein

1

6

High-throughput

0.470

High

770847

ECHP
Peroxisomal bifunctional enzyme

1

1

High-throughput

0.470

High

770848

Q08AM2
ADAM33 protein

1

2

High-throughput

0.470

High

770928

DOK5
Docking protein 5

1

3

Small-scale

0.464

High

377080

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

1

0

Small-scale

0.458

High

770863

GASP1
G-protein coupled receptor-associated sorting protein 1

1

6

Small-scale

0.457

High

770913

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

2

High-throughput

0.439

High

770925

TBA8
Tubulin alpha-8 chain

1

6

High-throughput

0.439

High

770856

TNIP1
TNFAIP3-interacting protein 1

1

2

Small-scale

0.437

High

770876

MMS22
Protein MMS22-like

2

0

High-throughput

0.328

High

186467

VA0E1
V-type proton ATPase subunit e 1

2

0

High-throughput

0.316

High

351664

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.316

High

770832

T4S4
Transmembrane 4 L6 family member 4

2

0

High-throughput

0.316

High

770833

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.316

High

770867

TM236
Transmembrane protein 236

2

0

High-throughput

0.316

High

770882

PLD3
5'-3' exonuclease PLD3

2

0

High-throughput

0.316

High

770885

CD302
CD302 antigen

2

0

High-throughput

0.316

High

770916

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

770926

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.316

High

770900

TECT2
Tectonic-2

1

0

High-throughput

0.269

Low

770834

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025