HitPredict

Interactor 1: SYNJ2 (O15056)
Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)
Gene: SYNJ2

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding GO:0061024 - membrane organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1496 Hs			1 639
+	Hs
		166055 SYNJ2_HUMAN (1-1496): 0: 1398: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		166042 SYNJ2_HUMAN (1-1496): 0: 1398: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		166030 SYNJ2_HUMAN (1-1496): 0: 1398: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		166056 SYNJ2_HUMAN (1-1496): 0: 1398: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		166049 SYNJ2_HUMAN (1-1496): 0: 1398: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Rn
		192744 SYNJ1_RAT (1-1492): 0: 1215: 41.06		SRBS2_RAT (6-215): 1.07e-19: 96.2: 18.87
+	Dm
		112574 Q5U0V7_DROME (1-1174): 0: 1056: 40.62		M9ND00_DROME (213-549): 1.1e-13: 76.9: 11.30
+	Ce
		105280 SYNJ_CAEEL (5-1135): 0: 940: 34.85		Q95PW9_CAEEL (109-333): 8.42e-19: 90.8: 21.68
+	Ce
		105281 SYNJ_CAEEL (5-1135): 0: 940: 34.85		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89
+	Hs
		1271571 SHIP1_HUMAN (449-1315): 9.89e-146: 478: 20.55		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1271562 SHIP1_HUMAN (449-1315): 9.89e-146: 478: 20.55		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		176485 SHIP2_HUMAN (454-1318): 6.35e-139: 462: 19.82		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Mm
		1246940 SHIP1_MOUSE (449-1311): 1.48e-144: 475: 20.44		SH3K1_MOUSE (1-638): 2.12e-83: 278: 30.09
+	Hs
		924742 SHIP1_HUMAN (449-1315): 9.89e-146: 478: 20.55		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141165 SHIP1_MOUSE (449-1311): 1.48e-144: 475: 20.44		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		176424 SHIP2_HUMAN (454-1318): 6.35e-139: 462: 19.82		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		557759 SHIP1_HUMAN (449-1315): 9.89e-146: 478: 20.55		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Mm
		1159873 SHIP2_MOUSE (454-1318): 7.57e-143: 472: 19.96		ITSN1_MOUSE (1-55): 4.64e-10: 65.3: 41.82
+	Hs
		176326 SHIP2_HUMAN (454-1318): 6.35e-139: 462: 19.82		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Hs
		176448 SHIP2_HUMAN (454-1318): 6.35e-139: 462: 19.82		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64